Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria
文献类型：期刊论文
| 作者 | Xiao, Mengqing2,3; Xia, Lin2; Tao, Yongzhen2,4; Yin, Huiyong1,2,3,4; Zhong, Huiqin3; Zhong, Huiqin1; Xia, Lin4; , |
| 刊名 | FREE RADICAL BIOLOGY AND MEDICINE
 |
| 出版日期 | 2017 |
| 卷号 | 111期号:SI页码:316-327 |
| 关键词 | Lipid peroxidation 4-hydroxy-2-nonenal (4-HNE) Mitochondrial dysfunction Neurodegenerative diseases Cancer Diabetes Cardiovascular disease |
| ISSN号 | 0891-5849 |
| DOI | 10.1016/j.freeradbiomed.2017.04.363 |
| 文献子类 | Review |
| 英文摘要 | Mitochondrial lipids are essential for maintaining the integrity of mitochondrial membranes and the proper functions of mitochondria. As the "powerhouse" of a cell, mitochondria are also the major cellular source of reactive oxygen species (ROS). Oxidative stress occurs when the antioxidant system is overwhelmed by overproduction of ROS. Polyunsaturated fatty acids in mitochondrial membranes are primary targets for ROS attack, which may lead to lipid peroxidation (LPO) and generation of reactive lipids, such as 4-hydroxynonenal. When mitochondrial lipids are oxidized, the integrity and function of mitochondria may be compromised and this may eventually lead to mitochondrial dysfunction, which has been associated with many human diseases including cancer, cardiovascular diseases, diabetes, and neurodegenerative diseases. How mitochondrial lipids are oxidized and the underlying molecular mechanisms and pathophysiological consequences associated with mitochondrial LPO remain poorly defined. Oxidation of the mitochondria-specific phospholipid cardiolipin and generation of bioactive lipids through mitochondrial LPO has been increasingly recognized as an important event orchestrating apoptosis, metabolic reprogramming of energy production, mitophagy, and immune responses. In this review, we focus on the current understanding of how mitochondrial LPO and generation of bioactive lipid mediators in mitochondria are involved in the modulation of mitochondrial functions in the context of relevant human diseases associated with oxidative stress. |
| 学科主题 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| WOS关键词 | FATTY-ACID OXIDATION ; TRAUMATIC BRAIN-INJURY ; PHOSPHOLIPASE A(2)GAMMA IPLA(2)GAMMA ; ALZHEIMERS-DISEASE ; PARKINSONS-DISEASE ; INSULIN-RESISTANCE ; REDOX PROTEOMICS ; HEART-FAILURE ; PERMEABILITY TRANSITION ; DILATED CARDIOMYOPATHY |
| 语种 | 英语 |
| WOS记录号 | WOS:000406049900028 |
| 出版者 | ELSEVIER SCIENCE INC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1074]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Beijing, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab food safety Res, Shanghai, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 4.Minist Hlth, Key Lab food safety risk Assessment, Beijing, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Xiao, Mengqing,Xia, Lin,Tao, Yongzhen,et al. Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria[J]. FREE RADICAL BIOLOGY AND MEDICINE,2017,111(SI):316-327. |
| APA | Xiao, Mengqing.,Xia, Lin.,Tao, Yongzhen.,Yin, Huiyong.,Zhong, Huiqin.,...&,.(2017).Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria.FREE RADICAL BIOLOGY AND MEDICINE,111(SI),316-327. |
| MLA | Xiao, Mengqing,et al."Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria".FREE RADICAL BIOLOGY AND MEDICINE 111.SI(2017):316-327. |
入库方式： OAI收割
来源：上海营养与健康研究所
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