PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling
文献类型：期刊论文
| 作者 | Wang, Lin1; Pan, Yi1; Huang, Meiqin1; You, Xue1; Guo, Feifan1; Chen, Yan1,2; You, Xue2; , |
| 刊名 | CELLULAR SIGNALLING
 |
| 出版日期 | 2017 |
| 卷号 | 33期号:-页码:98-106 |
| 关键词 | Autophagy mTOR mTORC1 PAQR3 Nutrient sensing |
| ISSN号 | 0898-6568 |
| DOI | 10.1016/j.cellsig.2017.02.017 |
| 文献子类 | Article |
| 英文摘要 | Amino acids are the key activators of the mTOR complex 1 (mTORC1, mainly composed of mTOR, Raptor and mLST8) required for cell growth and proliferation. On the other hand, deprivation of amino acids induces autophagy via inhibition of mTORC1 signaling. We report here that amino acid-induced mTORC1 activity and amino acid deprivation-induced autophagy are regulated by PAQR3, a newly found tumor suppressor. At the cellular level, PAQR3 negatively regulates amino acid-induced activation of mTORC1. The N-terminal end of PAQR3 interacts with the WD domains of Raptor and mLST8 directly. PAQR3 reduces the interaction of mTOR with Raptor and mLST8, thus disrupts formation of intact mTORC1 complex. PAQR3 modulates leucine-induced alteration in cell size. In addition, PAQR3 knockdown reduces amino acid deprivation-induced autophagy. The inhibitory effect of PAQR3 knockdown on autophagy is abrogated by rapamycin treatment, indicating that PAQR3 modulates autophagy via its regulation on mTORC1 signaling. In conclusion, our finding reveals a new mode of regulation of mTORC1 signaling and autophagy by PAQR3 in response to alterations of amino acids. (C) 2017 Elsevier Inc. All rights reserved. |
| 学科主题 | Cell Biology |
| WOS关键词 | ENERGY HOMEOSTASIS ; MAMMALIAN-CELLS ; GOLGI-APPARATUS ; GROWTH-CONTROL ; TOR COMPLEXES ; RAG GTPASES ; NUTRIENT ; AMPK ; METABOLISM ; RAPTOR |
| 语种 | 英语 |
| WOS记录号 | WOS:000397683500011 |
| 出版者 | ELSEVIER SCIENCE INC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1075]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutrit Sci,CAS Key Lab Nutr & Metab, Shanghai 200031, Peoples R China; 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Wang, Lin,Pan, Yi,Huang, Meiqin,et al. PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling[J]. CELLULAR SIGNALLING,2017,33(-):98-106. |
| APA | Wang, Lin.,Pan, Yi.,Huang, Meiqin.,You, Xue.,Guo, Feifan.,...&,.(2017).PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling.CELLULAR SIGNALLING,33(-),98-106. |
| MLA | Wang, Lin,et al."PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling".CELLULAR SIGNALLING 33.-(2017):98-106. |
入库方式： OAI收割
来源：上海营养与健康研究所
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