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PAQR3 suppresses the proliferation, migration and tumorigenicity of human prostate cancer cells

文献类型：期刊论文

作者Huang, Wenqiang2; Guo, Weiwei2; You, Xue2; Pan, Yi2; Yang, Chenghua2; Chen, Yan2,3; You, Xue3; Dong, Zhenyang1; Jia, Gaozhen1; Yang, Chenghua4
刊名ONCOTARGET
出版日期2017
卷号8期号:33页码:53948-53958
关键词human prostate cancer PAQR3 cell proliferation cell migration tumor xenograft
ISSN号1949-2553
DOI10.18632/oncotarget.9807
文献子类Article
英文摘要As a newly discovered tumor suppressor, the potential function of PAQR3 in human prostate cancer has not been demonstrated. In this study, we report that PAQR3 is able to inhibit the growth and migration of human prostate cancer cells both in vitro and in vivo. Overexpression of PAQR3 inhibits the proliferation of PC3 and DU145 cells by both MTT and colony formation assays. Consistently, knockdown of PAQR3 enhances the proliferation of these cells. In wound-healing and transwell assays, overexpression of PAQR3 reduces the migration of PC3 and DU145 cells, while PAQR3 knockdown increases it. In a tumor xenograft model, overexpression of PAQR3 suppresses tumor growth of PC3 cells in vivo, while PAQR3 knockdown promotes the tumor growth. PAQR3 is also able to inhibit serum-induced phosphorylation of AKT and ERK in both PC3 and DU145 cells. In addition, PAQR3 suppresses the expression of epithelial-mesenchymal transition (EMT) markers in PC3 cells. Collectively, these data indicate that PAQR3 has a tumor suppressive activity in human prostate cancer cells and may stand out as a potential therapeutic target for prostate cancers.
学科主题Oncology ; Cell Biology
WOS关键词TUMOR-SUPPRESSOR ; CARCINOMA ; RKTG ; CHEMOTHERAPY ; RECEPTOR ; PLAYS
语种英语
WOS记录号WOS:000407826100005
出版者IMPACT JOURNALS LLC
版本出版稿
源URL[http://202.127.25.144/handle/331004/1076]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Second Mil Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai 200433, Peoples R China;
2.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Acad Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China;
3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China;
4.Second Mil Med Univ, Shanghai Changhai Hosp, Joint Ctr Translat Res Chron Dis, Shanghai 2000433, Peoples R China,
推荐引用方式
GB/T 7714		 Huang, Wenqiang,Guo, Weiwei,You, Xue,et al. PAQR3 suppresses the proliferation, migration and tumorigenicity of human prostate cancer cells[J]. ONCOTARGET,2017,8(33):53948-53958.
APA Huang, Wenqiang.,Guo, Weiwei.,You, Xue.,Pan, Yi.,Yang, Chenghua.,...&,.(2017).PAQR3 suppresses the proliferation, migration and tumorigenicity of human prostate cancer cells.ONCOTARGET,8(33),53948-53958.
MLA Huang, Wenqiang,et al."PAQR3 suppresses the proliferation, migration and tumorigenicity of human prostate cancer cells".ONCOTARGET 8.33(2017):53948-53958.

入库方式： OAI收割

来源：上海营养与健康研究所

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