Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20
文献类型：期刊论文
| 作者 | Liu, Gan2,3; Zhou, Luting2,3; Zhang, Hai2,3; Chen, Rong2,3; Zhang, Ye2,3; Li, Ling2,3; Lu, Jun-Yu2,3; Jiang, Hui2; Liu, Dong2; Qi, Shasha2 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:-页码:14824 |
| 关键词 | mineralocorticoid receptor endothelial cells angiogenesis STAT3 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms14824 |
| 文献子类 | Article |
| 英文摘要 | Hepatic de novo lipogenesis (DNL) converts carbohydrates into triglycerides and is known to influence systemic lipid homoeostasis. Here, we demonstrate that the zinc finger protein Zbtb20 is required for DNL. Mice lacking Zbtb20 in the liver exhibit hypolipidemia and reduced levels of liver triglycerides, along with impaired hepatic lipogenesis. The expression of genes involved in glycolysis and DNL, including that of two ChREBP isoforms, is decreased in livers of knockout mice. Zbtb20 binds to and enhances the activity of the ChREBP-alpha promoter, suggesting that altered metabolic gene expression is mainly driven by ChREBP. In addition, ChREBP-beta overexpression largely restores hepatic expression of genes involved in glucose and lipid metabolism, and increases plasma and liver triglyceride levels in knockout mice. Finally, we show that Zbtb20 ablation protects from diet-induced liver steatosis and improves hepatic insulin resistance. We suggest ZBTB20 is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | ELEMENT-BINDING PROTEIN ; STEAROYL-COA DESATURASE-1 ; ALPHA-FETOPROTEIN GENE ; FATTY-ACID SYNTHESIS ; DE-NOVO LIPOGENESIS ; X-RECEPTOR LXR ; INSULIN-RESISTANCE ; TRANSCRIPTION FACTOR ; THYROID-HORMONE ; XYLULOSE 5-PHOSPHATE |
| 语种 | 英语 |
| WOS记录号 | WOS:000397159700001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1078]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China, 2.Second Mil Med Univ, Dept Pathophysiol, Shanghai 200433, Peoples R China; 3.Second Mil Med Univ, Obes & Diabet Res Ctr, Shanghai 200433, Peoples R China; 4.Changhai Hosp, Dept Endocrinol, Shanghai 200433, Peoples R China; 5.Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai 200433, Peoples R China; 6.Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China; 7.Changhai Hosp, Dept Gen Surg, Shanghai 200433, Peoples R China; 8.Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78245 USA; |
| 推荐引用方式 GB/T 7714 | Liu, Gan,Zhou, Luting,Zhang, Hai,et al. Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20[J]. NATURE COMMUNICATIONS,2017,8(-):14824. |
| APA | Liu, Gan.,Zhou, Luting.,Zhang, Hai.,Chen, Rong.,Zhang, Ye.,...&,.(2017).Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20.NATURE COMMUNICATIONS,8(-),14824. |
| MLA | Liu, Gan,et al."Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20".NATURE COMMUNICATIONS 8.-(2017):14824. |
入库方式： OAI收割
来源：上海营养与健康研究所
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