Rapid Evolution of Genes Involved in Learning and Energy Metabolism for Domestication of the Laboratory Rat
文献类型：期刊论文
| 作者 | Zeng, Lin3,4; Li, Yan3; Otecko, Newton O.3,4; Liu, He-Qun3; Wang, Ming-Shan3; Wu, Dong-Dong3; Zhang, Ya-Ping3; Ming, Chen4; Su, Ling-Yan4; Ming, Chen5 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2017 |
| 卷号 | 34期号:12页码:3148-3153 |
| 关键词 | laboratory rat origin domestication artificial selection |
| ISSN号 | 0737-4038 |
| DOI | 10.1093/molbev/msx238 |
| 文献子类 | Article |
| 英文摘要 | The laboratory rat, widely used in biomedical research, is domesticated from wild brown rat. The origin and genetic mechanism underlying domestication of the laboratory rat remain largely elusive. In the present study, large scale genomes supported a single origin for the laboratory rat, possibly from a sister group to wild rats from Europe/Africa/Middle East. Genomic and transcriptomic analyses uncovered many artificially selected genes (e.g., FOXP2, B3GATT, and CLOCK) involved in the nervous system. These genes associate with learning ability and regulation of circadian rhythm, which likely enabled the successful domestication of the laboratory rat. Particularly, many genes, including mitochondrial genes responsible for energy metabolism, displayed a substantially increased expression in the brain of laboratory rats compared with wild rats. Our findings demystify the origin and evolution of this model animal, and provide insight into the process of its domestication. |
| 学科主题 | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
| WOS关键词 | CARBOHYDRATE EPITOPE ; ARTIFICIAL SELECTION ; NATURAL-SELECTION ; RNA-SEQ ; REVEALS ; TOPHAT ; FOXP2 ; DOG |
| 语种 | 英语 |
| WOS记录号 | WOS:000416178900010 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1083]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming, Yunnan, Peoples R China, 2.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mechanisms, Kunming, Yunnan, Peoples R China; 3.Chinese Acad Sci, State Key Lab Genet Resources & Evolut, Yunnan Lab Mol Biol Domest Anim, Kunming Inst Zool, Kunming, Yunnan, Peoples R China; 4.Univ Chinese Acad Sci, Beijing, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai, Peoples R China; 6.Yunnan Univ, State Key Lab Conservat & Utilizat Bioresources Yu, Kunming, Yunnan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zeng, Lin,Li, Yan,Otecko, Newton O.,et al. Rapid Evolution of Genes Involved in Learning and Energy Metabolism for Domestication of the Laboratory Rat[J]. MOLECULAR BIOLOGY AND EVOLUTION,2017,34(12):3148-3153. |
| APA | Zeng, Lin.,Li, Yan.,Otecko, Newton O..,Liu, He-Qun.,Wang, Ming-Shan.,...&,.(2017).Rapid Evolution of Genes Involved in Learning and Energy Metabolism for Domestication of the Laboratory Rat.MOLECULAR BIOLOGY AND EVOLUTION,34(12),3148-3153. |
| MLA | Zeng, Lin,et al."Rapid Evolution of Genes Involved in Learning and Energy Metabolism for Domestication of the Laboratory Rat".MOLECULAR BIOLOGY AND EVOLUTION 34.12(2017):3148-3153. |
入库方式： OAI收割
来源：上海营养与健康研究所
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