Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features
文献类型：期刊论文
| 作者 | Chen, Shirui2; Zhou, Kai1; Yang, Liguang3; Ding, Guohui3; Li, Hong3; , |
| 刊名 | BIOMED RESEARCH INTERNATIONAL
 |
| 出版日期 | 2017 |
| 卷号 | -期号:-页码:1204082 |
| ISSN号 | 2314-6133 |
| DOI | 10.1155/2017/1204082 |
| 文献子类 | Article |
| 英文摘要 | The incidence and histological type of esophageal cancer are highly variable depending on geographic location and race/ethnicity. Here we want to determine if racial difference exists in the molecular features of esophageal cancer. We firstly confirmed that the incidence rate of esophagus adenocarcinoma(EA) was higher in Whites than in Asians and Blacks, while the incidence of esophageal squamous cell carcinoma (ESCC) was highest in Asians. Then we compared the genome-wide somatic mutations, methylation, and gene expression to identify differential genes by race. The mutation frequencies of some genes in the same pathway showed opposite difference between Asian and White patients, but their functional effects to the pathway may be consistent. The global patterns of methylation and expression were similar, which reflected the common characteristics of ESCC tumors from different populations. A small number of genes had significant differences between Asians and Whites. More interesting, the racial differences of COL11A1 were consistent across multiple molecular levels, with higher mutation frequency, higher methylation, and lower expression in White patients. This indicated that COL11A1 might play important roles in ESCC, especially in White population. Additional studies are needed to further explore their functions in esophageal cancer. |
| 学科主题 | Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| WOS关键词 | BREAST-CANCER ; MUTATIONS ; GENES ; ADENOCARCINOMA ; METHYLATION ; ACTIVATION ; LANDSCAPE ; AMERICAN ; PATHWAY ; GENOME |
| 语种 | 英语 |
| WOS记录号 | WOS:000398783000001 |
| 出版者 | HINDAWI LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1084]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Nanjing Med Univ, Childrens Hosp, Nanjing 211166, Jiangsu, Peoples R China; 2.Shanghai High Sch, Shanghai 200231, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Chen, Shirui,Zhou, Kai,Yang, Liguang,et al. Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features[J]. BIOMED RESEARCH INTERNATIONAL,2017,-(-):1204082. |
| APA | Chen, Shirui,Zhou, Kai,Yang, Liguang,Ding, Guohui,Li, Hong,&,.(2017).Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features.BIOMED RESEARCH INTERNATIONAL,-(-),1204082. |
| MLA | Chen, Shirui,et al."Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features".BIOMED RESEARCH INTERNATIONAL -.-(2017):1204082. |
入库方式： OAI收割
来源：上海营养与健康研究所
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