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Prospective study of urinary prostaglandin E2 metabolite and pancreatic cancer risk

文献类型：期刊论文

作者Cui, Yong2; Shu, Xiao-Ou2; Yang, Gong2; Wen, Wanqing2; Cai, Qiuyin2; Zheng, Wei2; Li, Hong-Lan3; Gao, Yu-Tang3; Lan, Qing3; Xiang, Yong-Bing3
刊名INTERNATIONAL JOURNAL OF CANCER
出版日期2017
卷号141期号:12页码:2423-2429
关键词pancreatic cancer prostaglandin E2 metabolite biomarkers cancer risk body mass index
ISSN号0020-7136
DOI10.1002/ijc.31007
文献子类Article
英文摘要The cyclooxygenase 2 (COX-2) pathway is upregulated in many pancreatic cancer cells, and it is believed that carcinogenetic effects of COX-2 upregulation are largely through prostaglandin E2 (PGE2) overproduction. We tested this hypothesis by evaluating the association between urinary PGE2 metabolites (PGE-M), a biomarker of in vivo PGE2 overproduction, and pancreatic cancer risk. We conducted a case-control study with 722 subjects (239 cases and 483 controls) nested within two prospective cohort studies, the Shanghai Women's Health Study (SWHS) and Shanghai Men's Health Study (SMHS). Pre-diagnosis urine samples were measured for PGE-M using a liquid chromatography/tandem mass spectrometric method. Conditional logistic regression was used to estimate odds ratio (OR) and 95% confidence intervals (95%CI), with adjustment for potential confounders. Compared to those with the lowest urine level of PGE-M (the first quartile), individuals with higher urine levels of PGE-M had an increased risk of developing pancreatic cancer, with adjusted ORs (95%CI) of 1.63 (0.98-2.73), 1.55 (0.90-2.69) and 1.94 (1.07-3.51), for the second to the fourth quartile groups, respectively (p for trend=0.054). This dose-response positive association was more evident among those who had BMI <25 kg/m(2) than overweight individuals (p for interaction=0.058). After excluding cases diagnosed in the first year of follow-up and their matched controls, this positive association persisted (p for trend=0.037) and the interaction became statistically significant (p for interaction=0.017). Our study adds additional evidence that the COX-2 pathway is involved in pancreatic carcinogenesis and suggests that urinary PGE-M may serve as a biomarker for predicting pancreatic cancer risk.
学科主题Oncology
WOS关键词NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; SHANGHAI WOMENS HEALTH ; ASPIRIN USE ; CYCLOOXYGENASE-2 EXPRESSION ; E-2 METABOLITE ; BREAST-CANCER ; COLORECTAL ADENOMA ; PGE-M ; INFLAMMATION ; ADENOCARCINOMA
语种英语
WOS记录号WOS:000413549900008
出版者WILEY
版本出版稿
源URL[http://202.127.25.144/handle/331004/1085]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.NCI, Div Epidemiol & Genet, Bethesda, MD 20892 USA;
2.Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Sch Med, 2525 West End Ave,8th Floor, Nashville, TN 37203 USA;
3.Shanghai Jiao Tong Univ, Shanghai Canc Inst, Renji Hosp, Dept Epidemiol,Sch Med, Shanghai, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China,
推荐引用方式
GB/T 7714		 Cui, Yong,Shu, Xiao-Ou,Yang, Gong,et al. Prospective study of urinary prostaglandin E2 metabolite and pancreatic cancer risk[J]. INTERNATIONAL JOURNAL OF CANCER,2017,141(12):2423-2429.
APA Cui, Yong.,Shu, Xiao-Ou.,Yang, Gong.,Wen, Wanqing.,Cai, Qiuyin.,...&,.(2017).Prospective study of urinary prostaglandin E2 metabolite and pancreatic cancer risk.INTERNATIONAL JOURNAL OF CANCER,141(12),2423-2429.
MLA Cui, Yong,et al."Prospective study of urinary prostaglandin E2 metabolite and pancreatic cancer risk".INTERNATIONAL JOURNAL OF CANCER 141.12(2017):2423-2429.

入库方式： OAI收割

来源：上海营养与健康研究所

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