Prediction of the Ebola Virus Infection Related Human Genes Using Protein-Protein Interaction Network
文献类型：期刊论文
| 作者 | Cao, HuanHuan2; Feng, Yuan-Ming2; Zhang, Ning2; Zhao, Jia3; Zhang, YuHang4; Zhu, Liucun1; Wang, Yi1; Li, JiaRui1; , |
| 刊名 | COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
 |
| 出版日期 | 2017 |
| 卷号 | 20期号:7页码:638-646 |
| 关键词 | Ebola virus pathogenic mechanism shortest path human protein identification betweenness GO enrichment |
| ISSN号 | 1386-2073 |
| DOI | 10.2174/1386207320666170310114816 |
| 文献子类 | Article |
| 英文摘要 | Background: Ebola hemorrhagic fever (EHF) is caused by Ebola virus (EBOV). It is reported that human could be infected by EBOV with a high fatality rate. However, association factors between EBOV and host still tend to be ambiguous. Objective: According to the "guilt by association" (GBA) principle, proteins interacting with each other are very likely to function similarly or the same. Based on this assumption, we tried to obtain EBOV infection-related human genes in a protein-protein interaction network using Dijkstra algorithm. Conclusion: We hope it could contribute to the discovery of novel effective treatments. Finally, 15 genes were selected as potential EBOV infection-related human genes. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| WOS关键词 | NIEMANN-PICK C1 ; HEMORRHAGIC-FEVER ; BENZODIAZEPINE-RECEPTOR ; LYMPHOCYTE APOPTOSIS ; CELLULAR ENTRY ; DC-SIGN ; IDENTIFICATION ; ACTIVATION ; INDUCTION ; CELLS |
| 语种 | 英语 |
| WOS记录号 | WOS:000413458200008 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1087]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai, Peoples R China, 2.Tianjin Univ, Tianjin Key Lab BME Measurement, Dept Biomed Engn, Tianjin, Peoples R China; 3.Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 4.CODBIO Co Ltd, Biomed Res Ctr, Tianjin, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cao, HuanHuan,Feng, Yuan-Ming,Zhang, Ning,et al. Prediction of the Ebola Virus Infection Related Human Genes Using Protein-Protein Interaction Network[J]. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,2017,20(7):638-646. |
| APA | Cao, HuanHuan.,Feng, Yuan-Ming.,Zhang, Ning.,Zhao, Jia.,Zhang, YuHang.,...&,.(2017).Prediction of the Ebola Virus Infection Related Human Genes Using Protein-Protein Interaction Network.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,20(7),638-646. |
| MLA | Cao, HuanHuan,et al."Prediction of the Ebola Virus Infection Related Human Genes Using Protein-Protein Interaction Network".COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING 20.7(2017):638-646. |
入库方式： OAI收割
来源：上海营养与健康研究所
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