SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport
文献类型：期刊论文
| 作者 | Shan, Peipei6; Fan, Guangjian6; Sun, Lianhui6; Zhang, Shengping6; Wang, Chuangui6; Liu, Jinqin7; Wang, Weifang7; Hu, Chen8; Zhang, Xiaohong8; Zhai, Qiwei1 |
| 刊名 | CURRENT BIOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 27期号:15页码:2271-+ |
| ISSN号 | 0960-9822 |
| DOI | 10.1016/j.cub.2017.06.040 |
| 文献子类 | Article |
| 英文摘要 | Most eukaryotic mRNAs are polyadenylated in the nucleus, and the poly(A)-tail is required for efficient mRNA export and translation. However, mechanisms governing mRNA transport remain unclear. Here, we report that the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 acts as an energy sensor and negatively regulates poly(A) RNA transport via deacetylating a poly(A)-binding protein, PABP1. Upon energy starvation, SIRT1 interacts with and deacetylates PABP1 and deactivates its poly(A) RNA binding, leading to nuclear accumulation of PABP1 and poly(A) RNA and thus facilitating eukaryotic cells to attenuate protein synthesis and energy consumption to adapt to energy stress. Moreover, AMPK-directed SIRT1 phosphorylation is required for energy starvation-induced PABP1-SIRT1 association, PABP1 deacetylation, and poly(A) RNA nuclear retention. In addition, the SIRT1-PABP1 association is not specific to energy starvation but represents a common stress response. These observations provide insights into dynamic modulation of eukaryotic mRNA transport and translation, suggesting that the poly(A)-tail also provides a basis for eukaryotes to effectively shut down mature mRNA transport and thereby tailor protein synthesis to maintain energy homeostasis under stress conditions. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS关键词 | YEAST POLY(A)-BINDING PROTEIN ; MESSENGER-RNA EXPORT ; TRANSLATION INITIATION ; TRANSCRIPTION FACTORS ; CELL-PROLIFERATION ; NUCLEAR RETENTION ; GENE-EXPRESSION ; DNA-DAMAGE ; HEAT-SHOCK ; BINDING |
| 语种 | 英语 |
| WOS记录号 | WOS:000407034300023 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1088]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China; 2.China Med Univ, Coll Translat Med, Key Lab Med Cell Biol, Shenyang 110000, Peoples R China; 3.Shanxi Med Univ, Minist Educ, Key Lab Cellular Physiol, Taiyuan 030001, Shanxi, Peoples R China; 4.Shanghai Key Lab Fundus Dis, 100 Haining Rd, Shanghai 200080, Peoples R China, 5.Shanghai Jiao Tong Univ, Dept Ophthalmol, Shanghai Gen Hosp, Sch Med, Shanghai 201620, Peoples R China; 6.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Inst Translat Med, Shanghai 201620, Peoples R China; 7.East China Normal Univ, Shanghai Key Lab Regulatory Biol, Inst Biomed Sci, Shanghai 200241, Peoples R China; 8.Wayne State Univ, Sch Med, Dept Oncol, Karmanos Canc Inst, 4100 John R, Detroit, MI 48201 USA; |
| 推荐引用方式 GB/T 7714 | Shan, Peipei,Fan, Guangjian,Sun, Lianhui,et al. SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport[J]. CURRENT BIOLOGY,2017,27(15):2271-+. |
| APA | Shan, Peipei.,Fan, Guangjian.,Sun, Lianhui.,Zhang, Shengping.,Wang, Chuangui.,...&,.(2017).SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport.CURRENT BIOLOGY,27(15),2271-+. |
| MLA | Shan, Peipei,et al."SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport".CURRENT BIOLOGY 27.15(2017):2271-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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