RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice
文献类型：期刊论文
| 作者 | Zhao, Qun3; Yu, XianJun3; Zhang, HaiWei3; Liu, YongBo3; Zhang, XiXi3; Wu, XiaoXia3; Xie, Qun3; Li, Ming3; Zhang, Haibing3; Yu, XianJun4,5 |
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 19期号:4页码:798-808 |
| 关键词 | Genetics Issue 122 artificial RNA binding factors protein engineering splicing factors alternative splicing PUF scaffold RNA binding proteins cancer |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2017.04.011 |
| 文献子类 | Article |
| 英文摘要 | RIPK3 mediates cell death and regulates inflammatory responses. Although genetic studies have suggested that RIPK3-MLKL-mediated necroptosis leads to embryonic lethality in Fadd or Caspase-8-deficient mice, the exact mechanisms are not fully understood. Here, we generated Ripk3 mutant mice by altering the RIPK3 kinase domain (Ripk3(Delta/Delta) mice), thus abolishing its kinase activity. Ripk3(Delta/Delta) cells were resistant to necroptosis stimulation in vitro, and Ripk3(Delta/Delta) mice were protected from necroptotic diseases. Although the Ripk3(Delta/Delta) mutation rescued embryonic lethality in Fadd(-/-) embryos, Fadd(-/)-Ripk3(Delta/Delta) mice died within 1 day after birth due to massive inflammation. These results indicate that Ripk3 ablation rescues embryonic lethality in Fadd-deficient mice by suppressing two RIPK3-mediating processes: necroptosis during embryogenesis and inflammation during postnatal development in Fadd(-/-) mice. |
| 学科主题 | Cell Biology |
| WOS关键词 | MIXED LINEAGE KINASE ; CHRONIC INTESTINAL INFLAMMATION ; DOMAIN-LIKE PROTEIN ; TNF-INDUCED NECROSIS ; PROGRAMMED NECROSIS ; CELL-DEATH ; NLRP3 INFLAMMASOME ; MOLECULAR-MECHANISMS ; PSEUDOKINASE MLKL ; INDUCED CYTOKINE |
| 语种 | 英语 |
| WOS记录号 | WOS:000401133700013 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1091]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Second Mil Med Univ, Changhai Hosp, Dept Anesthesiol, Shanghai 200433, Peoples R China; 2.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Acad Sci, Key Lab food safety Res,Inst Nutr Sci, Shanghai 200031, Peoples R China, 3.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Acad Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China; 4.Hubei Univ Med, Renmin Hosp, Oncol Ctr, Lab Chinese Herbal Pharmacol, Shiyan 442000, Peoples R China; 5.Hubei Univ Med, Sch Basic Med Sci, Shiyan 442000, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Qun,Yu, XianJun,Zhang, HaiWei,et al. RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice[J]. CELL REPORTS,2017,19(4):798-808. |
| APA | Zhao, Qun.,Yu, XianJun.,Zhang, HaiWei.,Liu, YongBo.,Zhang, XiXi.,...&,.(2017).RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice.CELL REPORTS,19(4),798-808. |
| MLA | Zhao, Qun,et al."RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice".CELL REPORTS 19.4(2017):798-808. |
入库方式： OAI收割
来源：上海营养与健康研究所
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