中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression

文献类型:期刊论文

作者Niu, Ningning4; Wang, Lijun4; Zou, Weiguo4; Xiang, Jian-Feng2; Yang, Qin3; Yang, Li3; Wei, Zhanying1; ,
刊名CELL DISCOVERY
出版日期2017
卷号3期号:-页码:UNSP 16050
关键词bone development chondrocyte Mig6 osteoblast SAMD4 translational repression
ISSN号2056-5968
DOI10.1038/celldisc.2016.50
文献子类Article
英文摘要Protein translation regulation has essential roles in inflammatory responses, cancer initiation and the pathogenesis of several neurodegenerative disorders. However, the role of the regulation of protein translation in mammalian skeleton development has been rarely elaborated. Here we report that the lack of the RNA-binding protein sterile alpha motif domain containing protein 4 (SAMD4) resulted in multiple developmental defects in mice, including delayed bone development and decreased osteogenesis. Samd4-deficient mesenchymal progenitors exhibit impaired osteoblast differentiation and function. Mechanism study demonstrates that SAMD4 binds the Mig6 mRNA and inhibits MIG6 protein synthesis. Consistent with this, Samd4-deficient cells have increased MIG6 protein level and knockdown of Mig6 rescues the impaired osteogenesis in Samd4-deficient cells. Furthermore, Samd4-deficient mice also display chondrocyte defects, which is consistent with the regulation of MIG6 protein level by SAMD4. These findings define SAMD4 as a previously unreported key regulator of osteoblastogenesis and bone development, implying that regulation of protein translation is an important mechanism governing skeletogenesis and that control of protein translation could have therapeutic potential in metabolic bone diseases, such as osteoporosis.
学科主题Cell Biology
WOS关键词NANOS MESSENGER-RNA ; OSTEOBLAST FUNCTION ; GENE-EXPRESSION ; STEM-CELLS ; SMAUG ; BONE ; DROSOPHILA ; STRESS ; KINASE ; DESTABILIZATION
语种英语
WOS记录号WOS:000414901200001
出版者NATURE PUBLISHING GROUP
版本出版稿
源URL[http://202.127.25.144/handle/331004/1096]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Metab Bone Dis & Genet Res Unit, Div Osteoporosis & Bone Dis,Dept Endocrinol & Met, Shanghai, Peoples R China,
2.Chinese Acad Sci, State Key Lab Mol Biol, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China;
3.Chinese Acad Sci, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China;
4.Chinese Acad Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China;
推荐引用方式
GB/T 7714
Niu, Ningning,Wang, Lijun,Zou, Weiguo,et al. RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression[J]. CELL DISCOVERY,2017,3(-):UNSP 16050.
APA Niu, Ningning.,Wang, Lijun.,Zou, Weiguo.,Xiang, Jian-Feng.,Yang, Qin.,...&,.(2017).RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression.CELL DISCOVERY,3(-),UNSP 16050.
MLA Niu, Ningning,et al."RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression".CELL DISCOVERY 3.-(2017):UNSP 16050.

入库方式: OAI收割

来源:上海营养与健康研究所

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