RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression
文献类型：期刊论文
| 作者 | Niu, Ningning4; Wang, Lijun4; Zou, Weiguo4; Xiang, Jian-Feng2; Yang, Qin3; Yang, Li3; Wei, Zhanying1; , |
| 刊名 | CELL DISCOVERY
 |
| 出版日期 | 2017 |
| 卷号 | 3期号:-页码:UNSP 16050 |
| 关键词 | bone development chondrocyte Mig6 osteoblast SAMD4 translational repression |
| ISSN号 | 2056-5968 |
| DOI | 10.1038/celldisc.2016.50 |
| 文献子类 | Article |
| 英文摘要 | Protein translation regulation has essential roles in inflammatory responses, cancer initiation and the pathogenesis of several neurodegenerative disorders. However, the role of the regulation of protein translation in mammalian skeleton development has been rarely elaborated. Here we report that the lack of the RNA-binding protein sterile alpha motif domain containing protein 4 (SAMD4) resulted in multiple developmental defects in mice, including delayed bone development and decreased osteogenesis. Samd4-deficient mesenchymal progenitors exhibit impaired osteoblast differentiation and function. Mechanism study demonstrates that SAMD4 binds the Mig6 mRNA and inhibits MIG6 protein synthesis. Consistent with this, Samd4-deficient cells have increased MIG6 protein level and knockdown of Mig6 rescues the impaired osteogenesis in Samd4-deficient cells. Furthermore, Samd4-deficient mice also display chondrocyte defects, which is consistent with the regulation of MIG6 protein level by SAMD4. These findings define SAMD4 as a previously unreported key regulator of osteoblastogenesis and bone development, implying that regulation of protein translation is an important mechanism governing skeletogenesis and that control of protein translation could have therapeutic potential in metabolic bone diseases, such as osteoporosis. |
| 学科主题 | Cell Biology |
| WOS关键词 | NANOS MESSENGER-RNA ; OSTEOBLAST FUNCTION ; GENE-EXPRESSION ; STEM-CELLS ; SMAUG ; BONE ; DROSOPHILA ; STRESS ; KINASE ; DESTABILIZATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000414901200001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1096]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Metab Bone Dis & Genet Res Unit, Div Osteoporosis & Bone Dis,Dept Endocrinol & Met, Shanghai, Peoples R China, 2.Chinese Acad Sci, State Key Lab Mol Biol, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China; 3.Chinese Acad Sci, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China; 4.Chinese Acad Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Niu, Ningning,Wang, Lijun,Zou, Weiguo,et al. RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression[J]. CELL DISCOVERY,2017,3(-):UNSP 16050. |
| APA | Niu, Ningning.,Wang, Lijun.,Zou, Weiguo.,Xiang, Jian-Feng.,Yang, Qin.,...&,.(2017).RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression.CELL DISCOVERY,3(-),UNSP 16050. |
| MLA | Niu, Ningning,et al."RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression".CELL DISCOVERY 3.-(2017):UNSP 16050. |
入库方式： OAI收割
来源：上海营养与健康研究所
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