SysFinder: A customized platform for search, comparison and assisted design of appropriate animal models based on systematic similarity
文献类型：期刊论文
| 作者 | Yang, Shuang2,3; Li, Yixue2,3,4; Zhang, Guoqing3; Liu, Wan3; Wang, Zhen4; Zhang, Jifeng5; Yang, Dongshan5; Chen, Y. Eugene5; Sun, Hong1; Li, Yixue6 |
| 刊名 | JOURNAL OF GENETICS AND GENOMICS
 |
| 出版日期 | 2017 |
| 卷号 | 44期号:5页码:251-258 |
| ISSN号 | 1673-8527 |
| 关键词 | Database Animal models Function similarity |
| DOI | 10.1016/j.jgg.2017.05.001 |
| 文献子类 | Article |
| 英文摘要 | Animal models are increasingly gaining values by cross-comparisons of response or resistance to clinical agents used for patients. However, many disease mechanisms and drug effects generated from animal models are not transferable to human. To address these issues, we developed SysFinder (http://lifecenter. sgst.cn/SysFinder), a platform for scientists to find appropriate animal models for translational research. SysFinder offers a "topic-centered" approach for systematic comparisons of human genes, whose functions are involved in a specific scientific topic, to the corresponding homologous genes of animal models. Scientific topic can be a certain disease, drug, gene function or biological pathway. SysFinder calculates multi-level similarity indexes to evaluate the similarities between human and animal models in specified scientific topics. Meanwhile, SysFinder offers species-specific information to investigate the differences in molecular mechanisms between humans and animal models. Furthermore, SysFinder provides a user-friendly platform for determination of short guide RNAs (sgRNAs) and homology arms to design a new animal model. Case studies illustrate the ability of SysFinder in helping experimental scientists. SysFinder is a useful platform for experimental scientists to carry out their research in the human molecular mechanisms. Copyright (C) 2017, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS关键词 | ONLINE MENDELIAN INHERITANCE ; MOUSE MODELS ; HUMAN-CELLS ; LUPUS-ERYTHEMATOSUS ; ABC TRANSPORTERS ; HUMAN-DISEASE ; CANCER ; MICE ; POLYMORPHISM ; BIOLOGY |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| WOS记录号 | WOS:000402828200005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1101]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Childrens Hosp Shanghai, Biomed Informat Res Ctr, Shanghai 200040, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Dept Bioinformat & Biostat, Shanghai 200240, Peoples R China; 3.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China; 5.Univ Michigan, Med Ctr, Ctr Adv Models Translat Sci & Therapeut, 1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA; 6.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai 200433, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Yang, Shuang,Li, Yixue,Zhang, Guoqing,et al. SysFinder: A customized platform for search, comparison and assisted design of appropriate animal models based on systematic similarity[J]. JOURNAL OF GENETICS AND GENOMICS,2017,44(5):251-258. |
| APA | Yang, Shuang.,Li, Yixue.,Zhang, Guoqing.,Liu, Wan.,Wang, Zhen.,...&,.(2017).SysFinder: A customized platform for search, comparison and assisted design of appropriate animal models based on systematic similarity.JOURNAL OF GENETICS AND GENOMICS,44(5),251-258. |
| MLA | Yang, Shuang,et al."SysFinder: A customized platform for search, comparison and assisted design of appropriate animal models based on systematic similarity".JOURNAL OF GENETICS AND GENOMICS 44.5(2017):251-258. |
入库方式： OAI收割
来源：上海营养与健康研究所
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