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Synthesis of polypyrrole nanowires with positive effect on MC3T3-E1 cell functions through electrical stimulation

文献类型：期刊论文

作者He, Yuan1; Wang, Shihui1; Mu, Jing1; Dai, Lingfeng1; Sun, Yanan1; Shi, Wei1; Ge, Dongtao1; Mu, Jing2; Zhang, Zhong3; ,
刊名MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
出版日期2017
卷号71期号:-页码:43-50
关键词Polypyrrole Nanostructure Electrical stimulation MC3T3-E1 Titanium
ISSN号0928-4931
DOI10.1016/j.msec.2016.09.067
文献子类Article
英文摘要Conducting polymer polypyrrole (PPy) possesses good biocompatibility and conductivity and has been used as functional coatings in bone tissue regeneration. In this study, a cholic acid doped PPy nanowires (PPy NWs) coating was electrochemically polymerized on the surface of titanium (Ti). The porous intertwined PPy NWs coating exhibited excellent electrical conductivity and electrochemical activity, better hydrophilicity and higher surface energy. In vitro cell experiments demonstrated that the PPy NWs coating together with a 10 A substrate-mediate electrical stimulation (ES) was capable to positive regulate the functions of MCT3-E1 such as cell adhesion, proliferation and differentiation. Further long-term functions of cell tests including alkaline phosphatase (ALP) activity, bone-carboxyglutamic acid-containing protein (BGP) and calcium deposition were all thoroughly increased. These confirmed that the combination of PPy NWs and ES could accelerate MC3T3-E1 cells mature and osteogenesis. Hence, the PPy NWs coating was an electro bioactive coating and may have potential applications in the treatment of bone damage repairing and regeneration with ES. (C) 2016 Published by Elsevier B.V.
学科主题Materials Science
WOS关键词IN-VITRO ; SURFACE MODIFICATION ; PROTEIN ADSORPTION ; TITANIUM-ALLOYS ; DIFFERENTIATION ; PROLIFERATION ; ADHESION ; FILMS ; OSTEOGENESIS ; SCAFFOLDS
语种英语
WOS记录号WOS:000390967200006
出版者ELSEVIER SCIENCE BV
版本出版稿
源URL[http://202.127.25.144/handle/331004/1104]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Xiamen Univ, Coll Mat, Dept Biomat, Xiamen 361005, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Partner Inst Computat Biol, Shanghai 200031, Peoples R China;
3.Xiamen Univ, Affiliated Zhongshan Hosp, Dept Stomatol, Xiamen 361005, Peoples R China,
推荐引用方式
GB/T 7714		 He, Yuan,Wang, Shihui,Mu, Jing,et al. Synthesis of polypyrrole nanowires with positive effect on MC3T3-E1 cell functions through electrical stimulation[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,71(-):43-50.
APA He, Yuan.,Wang, Shihui.,Mu, Jing.,Dai, Lingfeng.,Sun, Yanan.,...&,.(2017).Synthesis of polypyrrole nanowires with positive effect on MC3T3-E1 cell functions through electrical stimulation.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,71(-),43-50.
MLA He, Yuan,et al."Synthesis of polypyrrole nanowires with positive effect on MC3T3-E1 cell functions through electrical stimulation".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 71.-(2017):43-50.

入库方式： OAI收割

来源：上海营养与健康研究所

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