The PRC2-binding long non-coding RNAs in human and mouse genomes are associated with predictive sequence features
文献类型：期刊论文
| 作者 | Tu, Shiqi2,3; Shao, Zhen2; Yuan, Guo-Cheng1,4,5; , |
| 刊名 | Scientific Reports
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:41669 |
| 关键词 | extracellular vesicle tumor microenvironment therapeutic resistance diagnosis and prognosis targeting strategy |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep41669 |
| 文献子类 | Article |
| 英文摘要 | Recently, long non-coding RNAs (lncRNAs) have emerged as an important class of molecules involved in many cellular processes. One of their primary functions is to shape epigenetic landscape through interactions with chromatin modifying proteins. However, mechanisms contributing to the specificity of such interactions remain poorly understood. Here we took the human and mouse lncRNAs that were experimentally determined to have physical interactions with Polycomb repressive complex 2 (PRC2), and systematically investigated the sequence features of these lncRNAs by developing a new computational pipeline for sequences composition analysis, in which each sequence is considered as a series of transitions between adjacent nucleotides. Through that, PRC2-binding lncRNAs were found to be associated with a set of distinctive and evolutionarily conserved sequence features, which can be utilized to distinguish them from the others with considerable accuracy. We further identified fragments of PRC2-binding lncRNAs that are enriched with these sequence features, and found they show strong PRC2-binding signals and are more highly conserved across species than the other parts, implying their functional importance. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | EMBRYONIC STEM-CELLS ; MARKOV-CHAINS ; EPIGENETIC REGULATION ; GENE-EXPRESSION ; CHROMATIN ; PRC2 ; BINDING ; EVOLUTION ; PROTEINS ; IDENTIFICATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000393094000001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1106]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA; 2.Chinese Acad Sci, Key Lab Computat Biol, Collaborat Innovat Ctr Genet & Dev Biol, Max Planck Soc Partner Inst Computat Biol,Shangha, Shanghai 200031, Peoples R China; 3.Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02215 USA; 5.Harvard Stem Cell Inst, Cambridge, MA 02138 USA, |
| 推荐引用方式 GB/T 7714 | Tu, Shiqi,Shao, Zhen,Yuan, Guo-Cheng,et al. The PRC2-binding long non-coding RNAs in human and mouse genomes are associated with predictive sequence features[J]. Scientific Reports,2017,7(-):41669. |
| APA | Tu, Shiqi,Shao, Zhen,Yuan, Guo-Cheng,&,.(2017).The PRC2-binding long non-coding RNAs in human and mouse genomes are associated with predictive sequence features.Scientific Reports,7(-),41669. |
| MLA | Tu, Shiqi,et al."The PRC2-binding long non-coding RNAs in human and mouse genomes are associated with predictive sequence features".Scientific Reports 7.-(2017):41669. |
入库方式： OAI收割
来源：上海营养与健康研究所
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