The role of metals in mammalian olfaction of low molecular weight organosulfur compounds
文献类型：期刊论文
| 作者 | Block, Eric2; Batista, Victor S.1; Ahmed, Lucky1; Matsunami, Hiroaki4; Zhuang, Hanyi3; , |
| 刊名 | NATURAL PRODUCT REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 34期号:5页码:529-557 |
| 关键词 | FGF21 fasting lysosome autophagy lipid TFEB |
| ISSN号 | 0265-0568 |
| DOI | 10.1039/c7np00016b |
| 文献子类 | Review |
| 英文摘要 | While suggestions concerning the possible role ofmetals in olfaction and taste date back 50 years, only recently has it been possible to confirm these proposals with experiments involving individual olfactory receptors (ORs). A detailed discussion of recent experimental results demonstrating the key role of metals in enhancing the response of human and other vertebrate ORs to specific odorants is presented against the backdrop of our knowledge of how the sense of smell functions both at the molecular and whole animal levels. This review emphasizes the role of metals in the detection of low molecular weight thiols, sulfides, and other organosulfur compounds, including those found in strong-smelling animal excretions and plant volatiles, and those used in gas odorization. Alternative theories of olfaction are described, with evidence favoring the modified "shape" theory. The use of quantum mechanical/molecular modeling (QM/MM), site-directed mutagenesis and saturation-transfer-difference (STD) NMR is discussed, providing support for biological studies of mouse and human receptors, MOR244-3 and OR OR2T11, respectively. Copper is bound at the active site of MOR244-3 by cysteine and histidine, while cysteine, histidine and methionine are involved with OR2T11. The binding pockets of these two receptors are found in different locations in the three-dimensional seven transmembrane models. Another recently deorphaned human olfactory receptor, OR2M3, highly selective for a thiol from onions, and a broadly-tuned thiol receptor, OR1A1, are also discussed. Other topics covered include the effects of nanoparticles and heavy metal toxicants on vertebrate and fish ORs, intranasal zinc products and the loss of smell (anosmia). |
| 学科主题 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| WOS关键词 | HUMAN ODORANT RECEPTOR ; BAT-POLLINATED PLANTS ; SPECTROMETRY DART-MS ; HUMULUS-LUPULUS L. ; KEY FOOD ODORANT ; ZINC NANOPARTICLES ; DIMETHYL SULFIDE ; NOBEL LECTURE ; IN-VIVO ; VIBRATIONAL THEORY |
| 语种 | 英语 |
| WOS记录号 | WOS:000401029800007 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1107]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Yale Univ, Dept Chem, New Haven, CT 06520 USA; 2.SUNY Albany, Univ Albany, Dept Chem, Albany, NY 12222 USA; 3.Chinese Acad Sci, Shanghai Jiaotong Univ, Sch Med, Inst Hlth Sci,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China, 4.Duke Univ, Med Ctr, Duke Inst Brain Sci, Dept Mol Genet & Microbiol,Dept Neurobiol, Durham, NC 27710 USA; |
| 推荐引用方式 GB/T 7714 | Block, Eric,Batista, Victor S.,Ahmed, Lucky,et al. The role of metals in mammalian olfaction of low molecular weight organosulfur compounds[J]. NATURAL PRODUCT REPORTS,2017,34(5):529-557. |
| APA | Block, Eric,Batista, Victor S.,Ahmed, Lucky,Matsunami, Hiroaki,Zhuang, Hanyi,&,.(2017).The role of metals in mammalian olfaction of low molecular weight organosulfur compounds.NATURAL PRODUCT REPORTS,34(5),529-557. |
| MLA | Block, Eric,et al."The role of metals in mammalian olfaction of low molecular weight organosulfur compounds".NATURAL PRODUCT REPORTS 34.5(2017):529-557. |
入库方式： OAI收割
来源：上海营养与健康研究所
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