The Evolution and Expression Pattern of Human Overlapping lncRNA and Protein-coding Gene Pairs
文献类型：期刊论文
| 作者 | Ning, Qianqian2,3; Li, Yixue2,3; Li, Yixue4,5; Wang, Zhen4; Zhou, Songwen6; Sun, Hong1; Yu, Guangjun7; , |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:42775 |
| 关键词 | Furan fatty acids 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid Metabolism Renal failure Type 2 diabetes |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep42775 |
| 文献子类 | Article |
| 英文摘要 | Long non-coding RNA overlapping with protein-coding gene (lncRNA-coding pair) is a special type of overlapping genes. Protein-coding overlapping genes have been well studied and increasing attention has been paid to lncRNAs. By studying lncRNA-coding pairs in human genome, we showed that lncRNA-coding pairs were more likely to be generated by overprinting and retaining genes in lncRNA-coding pairs were given higher priority than non-overlapping genes. Besides, the preference of overlapping configurations preserved during evolution was based on the origin of lncRNA-coding pairs. Further investigations showed that lncRNAs promoting the splicing of their embedded protein-coding partners was a unilateral interaction, but the existence of overlapping partners improving the gene expression was bidirectional and the effect was decreased with the increased evolutionary age of genes. Additionally, the expression of lncRNA-coding pairs showed an overall positive correlation and the expression correlation was associated with their overlapping configurations, local genomic environment and evolutionary age of genes. Comparison of the expression correlation of lncRNA-coding pairs between normal and cancer samples found that the lineage-specific pairs including old protein-coding genes may play an important role in tumorigenesis. This work presents a systematically comprehensive understanding of the evolution and the expression pattern of human lncRNA-coding pairs. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | LONG NONCODING RNAS ; BIDIRECTIONAL PROMOTERS ; CHROMATIN SIGNATURE ; CANCER ; GENOME ; TRANSCRIPTION ; MAMMALS ; DROSOPHILA ; FRAMEWORK ; SELECTION |
| 语种 | 英语 |
| WOS记录号 | WOS:000397440800001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1113]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Childrens Hosp, Biomed Informat Res Ctr, Shanghai 200062, Peoples R China; 2.Shanghai Jiao Tong Univ, Dept Bioinformat & Biostat, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China; 3.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China; 4.Chinese Acad Sci, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 5.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China; 6.Tongji Univ, Sch Med, Dept Med Oncol, Shanghai Pulm Hosp,Canc Inst, Shanghai 200433, Peoples R China; 7.Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Shanghai 200062, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Ning, Qianqian,Li, Yixue,Li, Yixue,et al. The Evolution and Expression Pattern of Human Overlapping lncRNA and Protein-coding Gene Pairs[J]. SCIENTIFIC REPORTS,2017,7(-):42775. |
| APA | Ning, Qianqian.,Li, Yixue.,Li, Yixue.,Wang, Zhen.,Zhou, Songwen.,...&,.(2017).The Evolution and Expression Pattern of Human Overlapping lncRNA and Protein-coding Gene Pairs.SCIENTIFIC REPORTS,7(-),42775. |
| MLA | Ning, Qianqian,et al."The Evolution and Expression Pattern of Human Overlapping lncRNA and Protein-coding Gene Pairs".SCIENTIFIC REPORTS 7.-(2017):42775. |
入库方式： OAI收割
来源：上海营养与健康研究所
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