The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis
文献类型：期刊论文
| 作者 | Li, G.2,3,4; Hu, J.2,3,4; Lei, R.2,3,4; Hu, G.2,3,4; Li, M.5; Yin, H.5; Xiong, H.6; Ji, H.7; Wei, Q.1; , |
| 刊名 | ONCOGENE
 |
| 出版日期 | 2017 |
| 卷号 | 36期号:7页码:989-998 |
| 关键词 | Uyghurs Xinjiang Eurasia population structure genetic admixture SNP |
| ISSN号 | 0950-9232 |
| DOI | 10.1038/onc.2016.265 |
| 文献子类 | Article |
| 英文摘要 | Reprogrammed metabolism is one of the hallmarks of cancer. The dysregulation of glycolysis in cancer has been heavily studied. However, it remains largely unclear how other metabolic processes are regulated in cancer cells. Here we show that microRNA-182 (miR-182) suppresses pyruvate dehydrogenase (PDH) kinase 4 (PDK4) and promotes lung tumorigenesis. miR-182 is dysregulated and inversely correlated with PDK4 in human lung adenocarcinomas. The miR-182-PDK4 axis regulates lung cancer cell growth by modulating the activity of PDH, the gatekeeping enzyme of pyruvate flux into acetyl-CoA, and subsequently de novo lipogenesis of cancer cells. Suppression of lipogenesis by silencing ATP citrate lyase (ACLY) and fatty acid synthase (FASN) or by chemical inhibitors diminishes the effects of miR-182-PDK4 in tumor growth. Alteration of de novo lipogenesis also affects reactive oxygen species (ROS) production and the downstream JNK signaling pathway. Hence, our work suggests that the miR-182-PDK4 axis is a crucial regulator of cancer cell metabolism and a potential target for antitumor therapy. |
| 学科主题 | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| WOS关键词 | CANCER-CELL METABOLISM ; TARGETING HEXOKINASE 2 ; BREAST-CANCER ; AEROBIC GLYCOLYSIS ; GLUCOSE-METABOLISM ; MIR-182 EXPRESSION ; COLORECTAL-CANCER ; UP-REGULATION ; FATTY-ACID ; KINASE |
| 语种 | 英语 |
| WOS记录号 | WOS:000394169100011 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1117]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Tongji Univ, Sch Med, Dept Pathol, Shanghai Peoples Hosp 10, 301 Yanchang Rd, Shanghai 200072, Peoples R China, 2.Chinese Acad Sci, Key Lab Stem Cell Biol, Inst Hlth Sci, Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 4.Univ Chinese Acad Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 5.Chinese Acad Sci, Key Lab food safety Res, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China; 6.Huazhong Univ Sci & Technol, Tongji Hosp, Dept Oncol, Wuhan, Peoples R China; 7.Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, G.,Hu, J.,Lei, R.,et al. The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis[J]. ONCOGENE,2017,36(7):989-998. |
| APA | Li, G..,Hu, J..,Lei, R..,Hu, G..,Li, M..,...&,.(2017).The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis.ONCOGENE,36(7),989-998. |
| MLA | Li, G.,et al."The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis".ONCOGENE 36.7(2017):989-998. |
入库方式： OAI收割
来源：上海营养与健康研究所
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