The mitochondrial respiratory chain is essential for haematopoietic stem cell function
文献类型：期刊论文
| 作者 | Anso, Elena2; Weinberg, Samuel E.2; Diebold, Lauren P.2; Thompson, Benjamin J.2; Malinge, Sebastien2; Crispino, John D.2; Chandel, Navdeep S.2; Schumacker, Paul T.3; Liu, Xin4; Zhang, Yuannyu4 |
| 刊名 | NATURE CELL BIOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 19期号:6页码:614-+ |
| 关键词 | gastrointestinal stromal tumors dystrophin small molecules targeted therapy |
| ISSN号 | 1465-7392 |
| DOI | 10.1038/ncb3529 |
| 文献子类 | Article |
| 英文摘要 | Adult and fetal haematopoietic stem cells (HSCs) display a glycolytic phenotype, which is required for maintenance of stemness; however, whether mitochondrial respiration is required to maintain HSC function is not known. Here we report that loss of the mitochondrial complex III subunit Rieske iron-sulfur protein (RISP) in fetal mouse HSCs allows them to proliferate but impairs their differentiation, resulting in anaemia and prenatal death. RISP-null fetal HSCs displayed impaired respiration resulting in a decreased NAD(+)/NADH ratio. RISP-null fetal HSCs and progenitors exhibited an increase in both DNA and histone methylation associated with increases in 2-hydroxyglutarate (2HG), a metabolite known to inhibit DNA and histone demethylases. RISP inactivation in adult HSCs also impaired respiration resulting in loss of quiescence concomitant with severe pancytopenia and lethality. Thus, respiration is dispensable for adult or fetal HSC proliferation, but essential for fetal HSC differentiation and maintenance of adult HSC quiescence. |
| 学科主题 | Cell Biology |
| WOS关键词 | OXIDATIVE STRESS ; ONCOMETABOLITE 2-HYDROXYGLUTARATE ; REDUCTIVE CARBOXYLATION ; REGULATES QUIESCENCE ; METABOLIC-REGULATION ; EPIGENETIC MODIFIER ; ALPHA-KETOGLUTARATE ; ENERGY-METABOLISM ; BONE-MARROW ; RNA-SEQ |
| 语种 | 英语 |
| WOS记录号 | WOS:000402525200010 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1118]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China; 2.Robert H Lurie Canc Ctr, Dept Med, Chicago, IL 60611 USA; 3.Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA; 4.Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Childrens Med Ctr Res Inst, Dallas, TX 75390 USA; 5.Agios Pharmaceut, Cambridge, MA 02139 USA, |
| 推荐引用方式 GB/T 7714 | Anso, Elena,Weinberg, Samuel E.,Diebold, Lauren P.,et al. The mitochondrial respiratory chain is essential for haematopoietic stem cell function[J]. NATURE CELL BIOLOGY,2017,19(6):614-+. |
| APA | Anso, Elena.,Weinberg, Samuel E..,Diebold, Lauren P..,Thompson, Benjamin J..,Malinge, Sebastien.,...&,.(2017).The mitochondrial respiratory chain is essential for haematopoietic stem cell function.NATURE CELL BIOLOGY,19(6),614-+. |
| MLA | Anso, Elena,et al."The mitochondrial respiratory chain is essential for haematopoietic stem cell function".NATURE CELL BIOLOGY 19.6(2017):614-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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