Titanium dioxide nanoparticles prime a specific activation state of macrophages
文献类型：期刊论文
| 作者 | Huang, Chao2; Sun, Mayu2; Yang, Yang2; Wang, Feng2; Ma, Xueqi2; Ding, Qiurong2; Ying, Hao2; Song, Haiyun2; Wang, Hui2,3; Li, Jingquan3 |
| 刊名 | NANOTOXICOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 11期号:6页码:737-750 |
| ISSN号 | 1743-5390 |
| 关键词 | TiO2 NPs dietary exposure macrophage activation innate immunity |
| DOI | 10.1080/17435390.2017.1349202 |
| 文献子类 | Article |
| 英文摘要 | Titanium dioxide nanoparticles (TiO2 NPs) are widely used in foods, cosmetics, and medicine. Although the inhalation toxicity of TiO2 NPs has been studied, the potential adverse effects of oral exposure of low-dose TiO2 NPs are largely unclear. Herein, with macrophage cell lines, primary cells, and mouse models, we show that TiO2 NPs prime macrophages into a specific activation state characterized by excessive inflammation and suppressed innate immune function. After a month of dietary exposure in mice or exposure in vitro to TiO2 NPs (10 and 50 nm), the expressions of pro-inflammatory genes in macrophages were increased, and the expressions of anti-inflammatory genes were decreased. In addition, for macrophages exposed to TiO2 NPs in vitro and in vivo, their chemotactic, phagocytic, and bactericidal activities were lower. This imbalance in the immune system could enhance the susceptibility to infections. In mice, after a month of dietary exposure to low doses of TiO2 NPs, an aggravated septic shock occurred in response to lipopolysaccharide challenge, leading to elevated levels of inflammatory cytokines in serum and reduced overall survival. Moreover, TLR4-deficient mice and primary macrophages, or TLR4-independent stimuli, showed less response to TiO2 NPs. These results demonstrate that TiO2 NPs induce an abnormal state of macrophages characterized by excessive inflammation and suppressed innate immune function in a TLR4-dependent manner, which may suggest a potential health risk, particularly for those with additional complications, such as bacterial infections. |
| 学科主题 | Science & Technology - Other Topics ; Toxicology |
| WOS关键词 | PULMONARY INFLAMMATION ; RECEPTOR 4 ; FOOD-PRODUCTS ; HOST-DEFENSE ; EXPOSURE ; CELLS ; MODEL ; LPS ; NANOTECHNOLOGY ; INHALATION |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS LTD |
| WOS记录号 | WOS:000410909000003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1119]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Guangzhou Med Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab food safety Res, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Sch Publ Hlth, Shanghai, Peoples R China; 4.Tongji Univ, Sch Med, Inst Biomed Engn & Nanosci, Shanghai, Peoples R China; 5.Minist Hlth, Key Lab food safety risk Assessment, Beijing, Peoples R China; 6.Chinese Acad Sci, Shanghai Clin Ctr, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Huang, Chao,Sun, Mayu,Yang, Yang,et al. Titanium dioxide nanoparticles prime a specific activation state of macrophages[J]. NANOTOXICOLOGY,2017,11(6):737-750. |
| APA | Huang, Chao.,Sun, Mayu.,Yang, Yang.,Wang, Feng.,Ma, Xueqi.,...&,.(2017).Titanium dioxide nanoparticles prime a specific activation state of macrophages.NANOTOXICOLOGY,11(6),737-750. |
| MLA | Huang, Chao,et al."Titanium dioxide nanoparticles prime a specific activation state of macrophages".NANOTOXICOLOGY 11.6(2017):737-750. |
入库方式： OAI收割
来源：上海营养与健康研究所
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