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Towards Tyrosine Metabolism in Esophageal Squamous Cell Carcinoma

文献类型：期刊论文

作者Cheng, Jing2; Zheng, Guangyong3; Jin, Hai4; Gao, Xianfu1; ,
刊名COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
出版日期2017
卷号20期号:2页码:133-139
关键词ESCC metabolomics LC-MS/MS tyrosine metabolism diagnostic biomarker prediction model
ISSN号1386-2073
DOI10.2174/1386207319666161220115409
文献子类Article
英文摘要Background: Esophageal Squamous Cell Carcinoma (ESCC) is a common malignant tumor in China, which causes about 200,000 deaths each year. Sensitive biomarkers are helpful to diagnose the disease in early stage. Methods: To identify biomarkers of ESCC and elucidate underlying mechanism of the disease, a targeted metabolomics strategy based on liquid chromatography- tandem mass spectrometry (LCMS/MS) has been implemented to explore tyrosine metabolism from 40 ESCC patients and 27 healthy controls. Results: Four metabolites, i.e. phenylalanine, 4-hydroxyphenyllactic acid, 3,4-dihydroxyphenylalanine, and 3,4-dihydroxyphenylacetic acid were identified as diagnostic biomarkers for ESCC patients. Based on these biomarkers, a prediction model was constructed for ESCC diagnosis. The analysis of receiver operating characteristic (ROC) curve confirmed its effectiveness of the model. Conclusion: Our results reveal that tyrosine metabolism is disturbed in ESCC patients and the metabolites involved in tyrosine pathway can be used as diagnostic biomarkers of the disease. Findings of this study can help investigate pathogenesis of ESCC and facilitate understanding mechanism of the disease.
学科主题Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
WOS关键词CANCER ; DIAGNOSIS ; METABONOMICS ; METASTASIS ; GROWTH
语种英语
WOS记录号WOS:000402823500006
出版者BENTHAM SCIENCE PUBL LTD
版本出版稿
源URL[http://202.127.25.144/handle/331004/1121]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China,
2.Shanghai Univ Med & Hlth Sci, Dept Med Instrument, Shanghai 201318, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China;
4.Second Mil Med Univ, Changhai Hosp, Dept Cardiothorac Surg, Shanghai 200433, Peoples R China;
推荐引用方式
GB/T 7714		 Cheng, Jing,Zheng, Guangyong,Jin, Hai,et al. Towards Tyrosine Metabolism in Esophageal Squamous Cell Carcinoma[J]. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,2017,20(2):133-139.
APA Cheng, Jing,Zheng, Guangyong,Jin, Hai,Gao, Xianfu,&,.(2017).Towards Tyrosine Metabolism in Esophageal Squamous Cell Carcinoma.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,20(2),133-139.
MLA Cheng, Jing,et al."Towards Tyrosine Metabolism in Esophageal Squamous Cell Carcinoma".COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING 20.2(2017):133-139.

入库方式： OAI收割

来源：上海营养与健康研究所

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