ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression
文献类型：期刊论文
| 作者 | Ma, Qingyang1; Wu, Kai1; Li, Hui1,3; Li, Huichun1,3; Zhu, Yufei1; Hu, Guohong1; Hu, Landian1; Kong, Xiangyin1; Wu, Kai3; Li, Huichun2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2019 |
| 卷号 | 9期号:-页码:20021 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-019-56277-2 |
| 文献子类 | Article |
| 英文摘要 | Aberrant differentiation, driven by activation of normally silent tissue-specific genes, results in a switch of cell identity and often leads to cancer progression. The underlying genetic and epigenetic events are largely unexplored. Here, we report ectopic activation of the hepatobiliary-, intestinal- and neural-specific gene one cut homeobox 2 (ONECUT2) in various subtypes of lung cancer. ONECUT2 expression was associated with poor prognosis of RAS-driven lung adenocarcinoma. ONECUT2 overexpression promoted the malignant growth and invasion of A549 lung cancer cells in vitro, as well as xenograft tumorigenesis and bone metastases of these cells in vivo. Integrative transcriptomics and epigenomics analyses suggested that ONECUT2 promoted the trans-differentiation of lung cancer cells by preferentially targeting and regulating the activity of bivalent chromatin domains through modulating Polycomb Repressive Complex 2 (PRC2) occupancy. Our findings demonstrate that ONECUT2 is a lineage-specific and context-dependent oncogene in lung adenocarcinoma and suggest that ONECUT2 is a potential therapeutic target for these tumors. |
| 学科主题 | Oncology |
| WOS关键词 | TRANSCRIPTION FACTORS ; PROGRAM ; CANCER ; GENES ; CELLS |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31882655 |
| WOS记录号 | WOS:000509315700024 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1125]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China, 3.Univ Chinese Acad Sci, Beijing, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ma, Qingyang,Wu, Kai,Li, Hui,et al. ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression[J]. SCIENTIFIC REPORTS,2019,9(-):20021. |
| APA | Ma, Qingyang.,Wu, Kai.,Li, Hui.,Li, Huichun.,Zhu, Yufei.,...&,.(2019).ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression.SCIENTIFIC REPORTS,9(-),20021. |
| MLA | Ma, Qingyang,et al."ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression".SCIENTIFIC REPORTS 9.-(2019):20021. |
入库方式： OAI收割
来源：上海营养与健康研究所
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