YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation
文献类型：期刊论文
| 作者 | Huang, Hsinyi1,3,4; Zhang, Wenjing1,3,4; Pan, Yafang1,3,4; Gao, Yijun1,3,4; Li, Fuming1,3,4; Li, Fei1,3,4; Ma, Xueyan1,3,4; Hou, Shenda1,3,4; Li, Peixue1,3,4; Zhang, Lei1,2,3,4 |
| 刊名 | CANCER RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 77期号:21页码:5769-5781 |
| ISSN号 | 0008-5472 |
| 关键词 | Tibetan Mastiff gray wolf introgression adaptation |
| DOI | 10.1158/0008-5472.CAN-17-0449 |
| 文献子类 | Article |
| 英文摘要 | Lung squamous cell carcinoma (SCC), accounting for approximately 30% of non-small cell lung cancer, is often refractory to therapy. Screening a small-molecule library, we identified digitoxin as a high potency compound for suppressing human lung SCC growth in vitro and in vivo. Mechanistic investigations revealed that digitoxin attenuated YAP phosphorylation and promoted YAP nuclear sequestration. YAP activation led to excessive accumulation of reactive oxygen species (ROS) by downregulating the antioxidant enzyme GPX2 in a manner related to p63 blockade. In patient-derived xenograft models, digitoxin treatment efficiently inhibited lung SCC progression in correlation with reduced expression of YAP. Collectively, our results highlight a novel tumor-suppressor function of YAP via downregulation of GPX2 and ROS accumulation, with potential implications to improve precision medicine of human lung SCC. (C) 2017 AACR. |
| 学科主题 | Oncology |
| WOS关键词 | AMPK-MEDIATED REGULATION ; ORGAN SIZE CONTROL ; HIPPO PATHWAY ; INDUCED APOPTOSIS ; TUMOR-SUPPRESSOR ; CANCER-CELLS ; TRANSCRIPTIONAL ACTIVITY ; PROTEIN ; TEAD ; GROWTH |
| 语种 | 英语 |
| 出版者 | AMER ASSOC CANCER RESEARCH |
| WOS记录号 | WOS:000414248300040 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1126]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China; 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Innovat Ctr Cell Signaling Network, Shanghai, Peoples R China; 4.Chinese Acad Sci, State Key Lab Cell Biol, Shanghai, Peoples R China; 5.Tongji Univ, Sch Life Sci & Technol, Dept Bioinformat, Shanghai, Peoples R China; 6.Second Mil Med Univ, Changzheng Hosp, Kidney Inst CPLA, Dept Nephrol, Shanghai, Peoples R China; 7.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol, Inst Hlth Sci, Shanghai, Peoples R China; 8.Univ Chinese Acad Sci, Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China; 9.Peking Univ, Ctr Bioinformat, Sch Life Sci, Beijing, Peoples R China; 10.Fudan Univ, Shanghai Canc Ctr, Dept Thorac Surg, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Huang, Hsinyi,Zhang, Wenjing,Pan, Yafang,et al. YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation[J]. CANCER RESEARCH,2017,77(21):5769-5781. |
| APA | Huang, Hsinyi.,Zhang, Wenjing.,Pan, Yafang.,Gao, Yijun.,Li, Fuming.,...&,.(2017).YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation.CANCER RESEARCH,77(21),5769-5781. |
| MLA | Huang, Hsinyi,et al."YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation".CANCER RESEARCH 77.21(2017):5769-5781. |
入库方式： OAI收割
来源：上海营养与健康研究所
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