Twin-peak temporal regulation during human neocortical development
文献类型：期刊论文
| 作者 | Wang, Wei; Wang, Guang-Zhong; , |
| 刊名 | CELL DISCOVERY
 |
| 出版日期 | 2019 |
| 卷号 | 5期号:-页码:61 |
| 关键词 | Adiposity GSPE Gut microbiota High-fat diet Inflammation |
| ISSN号 | 1613-4125 |
| DOI | 10.1038/s41421-019-0129-3 |
| 文献子类 | Article |
| 英文摘要 | Understanding the temporal and spatial expression patterns of the human cerebral cortex is essential for expanding knowledge of its functionality. Previous analysis focused on the differentially expressed genes (DEGs) among cortical subregions revealed an hourglass model for interareal differences. However, the overall pattern of transcriptional differences during the development of every region remains to be fully explored. Here, analysing more than 800 neocortex samples from lifespan transcriptional profiles revealed that excitatory neurons are more regulated than inhibitory neurons in the foetal brain. Developmental DEGs tend to be resting state or memory encoding-related and are also involved in autism and Alzheimer's disease. In addition, twin peaks of DEGs occur during the development of each neocortex region, with a first peak appearing in the perinatal period and an unexpected second peak appearing around childhood. Genes in these peaks have similar functions, but the second peak is more inhibitory neuron related. All these results emphasize the significance of this unique temporal regulatory pattern for human neocortical development. |
| 学科主题 | Food Science & Technology |
| WOS关键词 | TRANSCRIPTOME ; NETWORK ; COEXPRESSION ; LANDSCAPE ; INSIGHTS ; PACKAGE |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31871735 |
| WOS记录号 | WOS:000502983000001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1128]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | Chinese Acad Sci, Univ Chinese Acad Sci, CAS MPG Partner Inst Computat Biol,Shanghai Inst, CAS Key Lab Computat Biol,Shanghai Inst Nutr & Hl, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Wang, Wei,Wang, Guang-Zhong,,. Twin-peak temporal regulation during human neocortical development[J]. CELL DISCOVERY,2019,5(-):61. |
| APA | Wang, Wei,Wang, Guang-Zhong,&,.(2019).Twin-peak temporal regulation during human neocortical development.CELL DISCOVERY,5(-),61. |
| MLA | Wang, Wei,et al."Twin-peak temporal regulation during human neocortical development".CELL DISCOVERY 5.-(2019):61. |
入库方式： OAI收割
来源：上海营养与健康研究所
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