Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis
文献类型：期刊论文
| 作者 | Zhang, Ying3,4,5; Cao, Chunwei3,5; Huang, Jiaojiao3,5; Hong, Qianlong3,5; Hai, Tang3,5; Jia, Qitao3,5; Wang, Xianlong3,5; Qin, Guosong3,5; Yao, Jing3,5; Wang, Xiao3,5 |
| 刊名 | BLOOD
 |
| 出版日期 | 2017 |
| 卷号 | 130期号:20页码:2161-2170 |
| ISSN号 | 0006-4971 |
| DOI | 10.1182/blood-2017-05-783043 |
| 文献子类 | Article |
| 英文摘要 | Congenital hypothyroidism (CH) is one of the most prevalent endocrine diseases, for which the underlying mechanisms remain unknown; it is often accompanied by anemia and immunodeficiency in patients. Here, we created a severe CH model together with anemia and T lymphopenia to mimic the clinical features of hypothyroid patients by ethylnitrosourea (ENU) mutagenesis in Bama miniature pigs. A novel recessive c.1226A>G transition of the dual oxidase 2 (DUOX2) gene was identified as the causative mutation. This mutation hindered the production of hydrogen peroxide (H2O2) and thus contributed to thyroid hormone (TH) synthesis failure. Transcriptome sequencing analysis of the thymuses showed that Kruppel-like factor 9 (KLF9) was predominantly downregulated in hypothyroid mutants. KLF9 was verified to be directly regulated by TH in a TH receptor (TR)-dependent manner both in vivo and in vitro. Furthermore, knockdown of klf9 in zebrafish embryos impaired hematopoietic development including erythroid maturation and T lymphopoiesis. Our findings suggest that the TR-KLF9 axis is responsible for the hematopoietic dysfunction and might be exploited for the development of novel therapeutic interventions for thyroid diseases. |
| 学科主题 | Hematology |
| WOS关键词 | GENETICALLY-MODIFIED PIGS ; CENTRAL-NERVOUS-SYSTEM ; CONGENITAL HYPOTHYROIDISM ; HUMAN-DISEASES ; GENE ; CELLS ; IDENTIFICATION ; REPLACEMENT ; MATURATION ; MUTATIONS |
| 语种 | 英语 |
| 出版者 | AMER SOC HEMATOLOGY |
| WOS记录号 | WOS:000415298400006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1129]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Third Mil Med Univ, Dept Lab Anim Sci, Coll Basic Med Sci, 29 Gaotanyan Rd, Chongqing 400038, Peoples R China, 2.Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China; 3.Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, 1 Beichen West Rd, Beijing 100101, Peoples R China; 4.Univ Chinese Acad Sci, Savaid Med Sch, Beijing, Peoples R China; 5.Chinese Swine Mutagenesis Consortium, Beijing, Peoples R China; 6.Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, 1 Beichen West Rd, Beijing 100101, Peoples R China; 7.Chinese Acad Sci, Inst Zool, Lab Anim Ctr, Beijing, Peoples R China; 8.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R China; 9.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab food safety Res, Shanghai, Peoples R China; 10.Northeast Agr Univ China, Coll Life Sci, Harbin, Heilongjiang, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Ying,Cao, Chunwei,Huang, Jiaojiao,et al. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis[J]. BLOOD,2017,130(20):2161-2170. |
| APA | Zhang, Ying.,Cao, Chunwei.,Huang, Jiaojiao.,Hong, Qianlong.,Hai, Tang.,...&,.(2017).Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis.BLOOD,130(20),2161-2170. |
| MLA | Zhang, Ying,et al."Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis".BLOOD 130.20(2017):2161-2170. |
入库方式： OAI收割
来源：上海营养与健康研究所
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