Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes
文献类型：期刊论文
| 作者 | Zhang, ShiQi2,3; Cai, Yu-Dong2; Pan, Xiaoyong5; Zeng, Tao6; Guo, Wei7,8; Gan, Zijun9; Zhang, Yu-Hang9; Huang, Tao9; Chen, Lei4,10; Zhang, YunHua1 |
| 刊名 | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 7期号:-页码:407 |
| 关键词 | copy number variation MACROD2 colorectal cancer subtype classification |
| ISSN号 | 2296-4185 |
| DOI | 10.3389/fbioe.2019.00407 |
| 文献子类 | Article |
| 英文摘要 | Copy number variation (CNV) is a common structural variation pattern of DNA, and it features a higher mutation rate than single-nucleotide polymorphisms (SNPs) and affects a larger fragment of genomes. CNV is related with the genesis of complex diseases and can thus be used as a strategy to identify novel cancer-predisposing markers or mechanisms. In particular, the frequent deletions of mono-ADP-ribosylhydrolase 2 (MACROD2) locus in human colorectal cancer (CRC) alters DNA repair and the sensitivity to DNA damage and results in chromosomal instability. The relationship between CNV and cancer has not been explained. In this study, on the basis of the genome variation profiling by the SNP array from 651 CRC primary tumors, we computationally analyzed the CNV data to select crucial SNP sites with the most relevance to three different states of MACROD2 (heterozygous deletion, homozygous deletion, and normal state), suggesting that these CNVs may play functional roles in CRC tumorigenesis. Our study can shed new insights into the genesis of cancer based on CNV, providing reference for clinical diagnosis, and treatment prognosis of CRC. |
| 学科主题 | Oncology ; Pathology |
| WOS关键词 | SUSCEPTIBILITY GENE ; DISEASE ; IDENTIFICATION ; RECEPTOR ; BREAST |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31921812 |
| WOS记录号 | WOS:000505179300001 |
| 出版者 | FRONTIERS MEDIA SA |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1132]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Anhui Agr Univ, Anhui Prov Key Lab Farmland Ecol Conservat & Poll, Sch Resources & Environm, Hefei, Anhui, Peoples R China, 2.Shanghai Univ, Sch Life Sci, Shanghai, Peoples R China; 3.Univ Copenhagen, Dept Biostat, Copenhagen, Denmark; 4.East China Normal Univ, Shanghai Key Lab PMMR, Shanghai, Peoples R China; 5.Shanghai Jiao Tong Univ, Inst Image Proc & Pattern Recognit, Key Lab Syst Control & Informat Proc, Minist Educ China, Shanghai, Peoples R China; 6.Chinese Acad Sci, Key Lab Syst Biol, Inst Biochem & Cell Biol, Shanghai, Peoples R China; 7.Shanghai Jiao Tong Univ, Inst Hlth Sci, Chinese Acad Sci, Sch Med, Shanghai, Peoples R China; 8.Shanghai Inst Biol Sci, Shanghai, Peoples R China; 9.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci, Shanghai, Peoples R China; 10.Shanghai Maritime Univ, Coll Informat Engn, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, ShiQi,Cai, Yu-Dong,Pan, Xiaoyong,et al. Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2019,7(-):407. |
| APA | Zhang, ShiQi.,Cai, Yu-Dong.,Pan, Xiaoyong.,Zeng, Tao.,Guo, Wei.,...&,.(2019).Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,7(-),407. |
| MLA | Zhang, ShiQi,et al."Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 7.-(2019):407. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。