Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures
文献类型：期刊论文
| 作者 | Jin, Daqing3,5; Fang, Yabo5; Yu, Gaihong3,5; Zhong, Tao P.3,5; Zhu, Diqi2; Chen, Yiwei2; Li, Fen2; Pan, Weijun4; Liu, Dong1; , |
| 刊名 | JOURNAL OF GENETICS AND GENOMICS
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| 出版日期 | 2017 |
| 卷号 | 44期号:10页码:483-492 |
| 关键词 | Vegfa TALEN Arterial-venous specification Zebrafish |
| ISSN号 | 1673-8527 |
| DOI | 10.1016/j.jgg.2017.07.005 |
| 文献子类 | Article |
| 英文摘要 | Vascular endothelial growth factor A (Vegfa) signaling regulates vascular development during embryogenesis and organ formation. However, the signaling mechanisms that govern the formation of various arteries/veins in various tissues are incompletely understood. In this study, we utilized transcription activator-like effector nuclease (TALEN) to generate zebrafish vegfaa mutants. vegfaa(-/-) embryos are embryonic lethal, and display a complete loss of the dorsal aorta (DA) and expansion of the cardinal vein. Activation of Vegfa signaling expands the arterial cell population at the expense of venous cells during vasculogenesis of the axial vessels in the trunk. Vegfa signaling regulates endothelial cell (EC) proliferation after arterial-venous specification. Vegfa deficiency and overexpression inhibit the formation of tip cell filopodia and interfere with the pathfinding of intersegmental vessels (ISVs). In the head vasculature, vegfaa(-/-) causes loss of a pair of mesencephalic veins (MsVs) and central arteries (CtAs), both of which usually develop via sprouting angiogenesis. Our results indicate that Vegfa signaling induces the formation of the DA at the expense of the cardinal vein during the trunk vasculogenesis, and that Vegfa is required for the angiogenic formation of MsVs and CtAs in the brain. These findings suggest that Vegfa signaling governs the formation of diverse arteries/veins by distinct cellular mechanisms in vertebrate vasculatures. Copyright (C) 2017, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS关键词 | ZEBRAFISH EMBRYOS ; ARTERIAL ; GENE ; DIFFERENTIATION ; ANGIOGENESIS ; DISRUPTION ; LETHALITY ; HINDBRAIN ; GRIDLOCK ; HEDGEHOG |
| 语种 | 英语 |
| WOS记录号 | WOS:000417047000003 |
| 出版者 | SCIENCE PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1136]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Nantong Univ, Jiangsu Key Lab Neuroregenerat, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China, 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Dept Pediat Cardiol, Shanghai 200127, Peoples R China; 3.East China Normal Univ, Sch Life Sci, Inst Mol Med, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China; 5.Fudan Univ, Zhong Shan Hosp, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200438, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Jin, Daqing,Fang, Yabo,Yu, Gaihong,et al. Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures[J]. JOURNAL OF GENETICS AND GENOMICS,2017,44(10):483-492. |
| APA | Jin, Daqing.,Fang, Yabo.,Yu, Gaihong.,Zhong, Tao P..,Zhu, Diqi.,...&,.(2017).Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures.JOURNAL OF GENETICS AND GENOMICS,44(10),483-492. |
| MLA | Jin, Daqing,et al."Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures".JOURNAL OF GENETICS AND GENOMICS 44.10(2017):483-492. |
入库方式： OAI收割
来源：上海营养与健康研究所
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