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L-Arabinose Inhibits Colitis by Modulating Gut Microbiota in Mice

文献类型：期刊论文

作者Li, Yan3; Pan, Haiou3; Liu, Jin-xin3; Fan, Mingcong3; Xue, Lamei3; Wang, Yu3; Nie, Chenzhipeng3; Zhang, Hui3; Qian, Haifeng3; Wang, Li3
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2019
卷号67期号:48页码:13299-13306
关键词L-arabinose IBD DSS colitis inflammation gut microbiota
ISSN号0021-8561
DOI10.1021/acs.jafc.9b05829
文献子类Article
英文摘要L-Arabinose is a monosaccharide extracted from plants or fibers, which is known to have a variety of functional properties. In this study, we aim to investigate whether L-arabinose could inhibit colitis by modulating gut microbiota. L-Arabinose was administered in mice daily in a dextran sodium sulfate (DSS)-induced colitis model. The histological analysis, disease index, and the expression of inflammatory genes were measured. 16S-rRNA sequence analysis was performed to investigate gut microbiota. Intriguingly, we found that L-arabinose could repress DSS-induced colitis and inhibit p38-/p65-dependent inflammation activation. Besides that, our data revealed that l-arabinose-modulated DSS-induced gut microbiota were disturbed. Additionally, the perturbed gut microbiota was responsible for the suppressive effects of L-arabinose on DSS-induced colitis treated with antibiotics. Lastly, Caco-2 cells were used to confirm the protective effects of L-arabinose in colitis or inflammatory bowel disease. As expected, the protein expression levels in Caco-2 cells of pro-inflammatory genes, which were treated with L-arabinose and incubated with or without tumor necrosis factor alpha. Our work suggested that L-arabinose exerts anti-inflammation effects in DSS-induced colitis. These beneficial effects have correlations with the composition, diversity, and abundance of the gut microbiota regulated by L-arabinose. L-Arabinose could be a remarkable candidate as a functional food or novel therapeutic strategy for intestinal health.
学科主题Biotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS关键词INFLAMMATORY-BOWEL-DISEASE ; RESPONSES ; SUCROSE
语种英语
CSCD记录号CSCD:31674784
WOS记录号WOS:000501620300010
出版者AMER CHEMICAL SOC
版本出版稿
源URL[http://202.127.25.144/handle/331004/1141]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr Metab & Food Safety, Shanghai 200031, Peoples R China,
2.Nanjing Forestry Univ, Coll Light Ind & Food Engn, Dept Food Sci & Engn, Nanjing 210037, Jiangsu, Peoples R China;
3.Jiangnan Univ, Sch Food Sci & Technol, Jiangsu Key Lab Adv Food Mfg Equipment & Technol, State Key Lab Food Sci & Technol, Nanjing 210037, Jiangsu, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Yan,Pan, Haiou,Liu, Jin-xin,et al. L-Arabinose Inhibits Colitis by Modulating Gut Microbiota in Mice[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(48):13299-13306.
APA Li, Yan.,Pan, Haiou.,Liu, Jin-xin.,Fan, Mingcong.,Xue, Lamei.,...&,.(2019).L-Arabinose Inhibits Colitis by Modulating Gut Microbiota in Mice.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(48),13299-13306.
MLA Li, Yan,et al."L-Arabinose Inhibits Colitis by Modulating Gut Microbiota in Mice".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.48(2019):13299-13306.

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来源：上海营养与健康研究所

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