Impact of Dietary Interventions on Noncoding RNA Networks and mRNAs Encoding Chromatin-Related Factors
文献类型：期刊论文
| 作者 | Green, Christopher D.3; Huang, Yi3; Dou, Xiaoyang3; Han, Jing-Dong J.3; Dou, Xiaoyang2; Yang, Liu1; Liu, Yong1; , |
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 18期号:12页码:2957-2968 |
| 关键词 | breast cancer metastasis to bone breast cancer bone cancer protein-protein interaction shortest path algorithm |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2017.03.001 |
| 文献子类 | Article |
| 英文摘要 | Dietary interventions dramatically affect metabolic disease and lifespan in various aging models. Here, we profiled liver microRNA (miRNA), coding, and long non-coding RNA (lncRNA) expression by high-throughput deep sequencing in mice across multiple energy intake and expenditure interventions. Strikingly, three dietary intervention network design patterns were uncovered: (1) lifespan-extending interventions largely repressed the expression of miRNAs, lncRNAs, and transposable elements; (2) protein-coding mRNAs with expression positively correlated with long lifespan are highly targeted by miRNAs; and (3) miRNA-targeting interactions mainly target chromatin-related functions. We experimentally validated miR-34a, miR-107, and miR-212-3p targeting of the chromatin remodeler Chd1 and further demonstrate that Chd1 knockdown mimics high-fat diet and aging-induced gene expression changes and activation of transposons. Our findings demonstrate lifespan-extending diets repress miRNA-chromatin remodeler interactions and safeguard against deregulated transcription induced by aging and lifespan shortening diets, events linked by microRNA, chromatin, and ncRNA crosstalk. |
| 学科主题 | Cell Biology |
| WOS关键词 | EMBRYONIC STEM-CELLS ; CALORIE RESTRICTION ; LIFE-SPAN ; MICRORNA ; TRANSCRIPTION ; LONGEVITY ; CHD1 ; METABOLISM ; SIRT1 ; YEAST |
| 语种 | 英语 |
| WOS记录号 | WOS:000397330200014 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1144]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China, 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Collaborat Innovat Ctr Genet & Dev Biol, Key Lab Computat Biol,CAS Ctr Excellence Mol Cell, Max Planck Partner Inst Computat Biol,Shanghai In, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Green, Christopher D.,Huang, Yi,Dou, Xiaoyang,et al. Impact of Dietary Interventions on Noncoding RNA Networks and mRNAs Encoding Chromatin-Related Factors[J]. CELL REPORTS,2017,18(12):2957-2968. |
| APA | Green, Christopher D..,Huang, Yi.,Dou, Xiaoyang.,Han, Jing-Dong J..,Dou, Xiaoyang.,...&,.(2017).Impact of Dietary Interventions on Noncoding RNA Networks and mRNAs Encoding Chromatin-Related Factors.CELL REPORTS,18(12),2957-2968. |
| MLA | Green, Christopher D.,et al."Impact of Dietary Interventions on Noncoding RNA Networks and mRNAs Encoding Chromatin-Related Factors".CELL REPORTS 18.12(2017):2957-2968. |
入库方式： OAI收割
来源：上海营养与健康研究所
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