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Increased complexity of circRNA expression during species evolution

文献类型：期刊论文

作者Dong, Rui2,4; Ma, Xu-Kai2,4; Yang, Li1,2,4; Chen, Ling-Ling1,3; Chen, Ling-Ling2; ,
刊名RNA BIOLOGY
出版日期2017
卷号14期号:8页码:1064-1074
关键词Alu back-splicing circRNA complementary sequence evolution SINE species-specific
ISSN号1547-6286
DOI10.1080/15476286.2016.1269999
文献子类Article
英文摘要Circular RNAs (circRNAs) are broadly identified from precursor mRNA (pre-mRNA) back-splicing across various species. Recent studies have suggested a cell-/tissue- specific manner of circRNA expression. However, the distinct expression pattern of circRNAs among species and its underlying mechanism still remain to be explored. Here, we systematically compared circRNA expression from human and mouse, and found that only a small portion of human circRNAs could be determined in parallel mouse samples. The conserved circRNA expression between human and mouse is correlated with the existence of orientation-opposite complementary sequences in introns that flank back-spliced exons in both species, but not the circRNA sequences themselves. Quantification of RNA pairing capacity of orientation-opposite complementary sequences across circRNA-flanking introns by Complementary Sequence Index (CSI) identifies that among all types of complementary sequences, SINEs, especially Alu elements in human, contribute the most for circRNA formation and that their diverse distribution across species leads to the increased complexity of circRNA expression during species evolution. Together, our integrated and comparative reference catalog of circRNAs in different species reveals a species-specific pattern of circRNA expression and suggests a previously under-appreciated impact of fast-evolved SINEs on the regulation of (circRNA) gene expression.
学科主题Biochemistry & Molecular Biology
WOS关键词CIRCULAR RNAS ; EXON CIRCULARIZATION ; BIOGENESIS ; LANDSCAPE ; ABUNDANT ; REVEALS ; TISSUES ; GENE
语种英语
WOS记录号WOS:000415997500013
出版者TAYLOR & FRANCIS INC
版本出版稿
源URL[http://202.127.25.144/handle/331004/1145]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China,
2.Univ Chinese Acad Sci, Beijing, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Mol Biol, Shanghai, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,CAS Ctr Excellence Brain Sc, Shanghai, Peoples R China;
推荐引用方式
GB/T 7714		 Dong, Rui,Ma, Xu-Kai,Yang, Li,et al. Increased complexity of circRNA expression during species evolution[J]. RNA BIOLOGY,2017,14(8):1064-1074.
APA Dong, Rui,Ma, Xu-Kai,Yang, Li,Chen, Ling-Ling,Chen, Ling-Ling,&,.(2017).Increased complexity of circRNA expression during species evolution.RNA BIOLOGY,14(8),1064-1074.
MLA Dong, Rui,et al."Increased complexity of circRNA expression during species evolution".RNA BIOLOGY 14.8(2017):1064-1074.

入库方式： OAI收割

来源：上海营养与健康研究所

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