Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea
文献类型：期刊论文
| 作者 | Chen, Qianqian1,2,3; Quan, Yizhou1,2,3; Wang, Naitao1; Ji, Zhongzhong1,2,3; Wei, Xunbin1,2,3; Gao, Wei-Qiang1,2,3,4; Xie, Chengying2,3; He, Hao2,3; Yin, Shankai3,4; He, Hao4 |
| 刊名 | STEM CELL REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:1页码:231-246 |
| ISSN号 | 2213-6711 |
| 关键词 | Lung adenocarcinoma Transcription factor Tumorigenesis Greedy algorithm |
| DOI | 10.1016/j.stemcr.2017.05.031 |
| 文献子类 | Article |
| 英文摘要 | Although STAT3 signaling is demonstrated to regulate sensory cell differentiation and regeneration in the zebrafish, its exact role is still unclear in mammalian cochleae. Here, we report that STAT3 and its activated form are specifically expressed in hair cells during mouse cochlear development. Importantly, conditional cochlear deletion of Stat3 leads to an inhibition on hair cell differentiation in mice in vivo and in vitro. By cell fate analysis, inactivation of STAT3 signaling shifts the cell division modes from asymmetric to symmetric divisions from supporting cells. Moreover, inhibition of Notch signaling stimulates STAT3 phosphorylation, and inactivation of STAT3 signaling attenuates production of supernumerary hair cells induced by a Notch pathway inhibitor. Our findings highlight an important role of the STAT3 signaling during mouse cochlear hair cell differentiation and may have clinical implications for the recovery of hair cell loss-induced hearing impairment. |
| 学科主题 | Cell Biology |
| WOS关键词 | MAMMALIAN INNER-EAR ; SUPPORTING CELLS ; BETA-CATENIN ; STEM-CELLS ; NOTCH ; REGENERATION ; GENERATION ; PATHWAY ; MATH1 ; FATE |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000405178400021 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1148]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Renji MedX Stem Cell Res Ctr, State Key Lab Oncogenes & Related Genes, Ren Ji Hosp,Sch Biomed Engn, Shanghai 200030, Peoples R China; 2.Shanghai Jiao Tong Univ, Med X Res Inst, Shanghai 200030, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China; 4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Med X Res Inst, Shanghai 200030, Peoples R China; 5.Southeast Univ, Inst Life Sci, MOE Key Lab Dev Genes & Human Dis, Nanjing 210096, Jiangsu, Peoples R China; 6.Fudan Univ, State Key Lab Med Neurobiol, Affiliated Eye & ENT Hosp, Otorhinolaryngol Dept, Shanghai 200031, Peoples R China; 7.Shanghai Jiao Tong Univ, Chinese Acad Sci, Shanghai Inst Biol Sci, China Key Lab Stem Cell Biol,Inst Hlth Sci,Sch Me, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Chen, Qianqian,Quan, Yizhou,Wang, Naitao,et al. Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea[J]. STEM CELL REPORTS,2017,9(1):231-246. |
| APA | Chen, Qianqian.,Quan, Yizhou.,Wang, Naitao.,Ji, Zhongzhong.,Wei, Xunbin.,...&,.(2017).Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea.STEM CELL REPORTS,9(1),231-246. |
| MLA | Chen, Qianqian,et al."Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea".STEM CELL REPORTS 9.1(2017):231-246. |
入库方式： OAI收割
来源：上海营养与健康研究所
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