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Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus

文献类型：期刊论文

作者Ye, Lei1,2,3; Li, Li1,2,3; Yang, Minglan1,2,3; Hong, Jie1,2,3; Gu, Weiqiong1,2,3; Wang, Weiqing1,2,3; Ning, Guang1,2,3; Wan, Bing4,5,6; Ning, Guang7; ,
刊名STEM CELL RESEARCH & THERAPY
出版日期2017
卷号8期号:-页码:90
ISSN号1757-6512
关键词Hematopoietic stem cell Type 1 diabetes mellitus Immune response Th1 cell Th17 cell Regulartory T cell
DOI10.1186/s13287-017-0542-1
文献子类Article
英文摘要Background: This study explored the details of the immune response after autologous hematopoietic stem cell transplantation (AHSCT) treatment in type 1 diabetes mellitus. Methods: Peripheral blood mononuclear cells (PBMCs) from 18 patients with type 1 diabetes mellitus were taken at baseline and 12 months after AHSCT or insulin-only therapy. The lymphocyte proliferation, mRNA expression and secretion of pro-inflammatory and anti-inflammatory cytokines belonging to T-helper type 1 (Th1), T-helper type 17 (Th17) and regulatory T (Treg) cells in PBMC culture supernatants were assessed. Results: Compared with patients receiving insulin-only treatment, the patients receiving AHSCT treatment showed better residual C-peptide secretion, lower anti-GAD titers and less exogenous insulin dosages after 12 months of follow-up. AHSCT treatment was associated with significantly reduced Th1 and Th17 cell proportions as well as decreased IFN-gamma, IL-2, IL-12p40 and IL-17A levels in the PBMC culture supernatants (all P < 0.05). Although there was no significant Treg cell expansion after AHSCT treatment, we observed increased IL-10, TGF-beta and Foxp3 mRNA expression and increased TGF-beta levels. However, we found no significant changes in the T-cell subpopulations after insulin treatment, except for higher IL-12p40 mRNA expression and a lower proportion of Treg cells. Conclusions: AHSCT treatment was associated with decreased expansion and function of Th1 and Th17 cells, which may explain the better therapeutic effect of AHSCT compared with the traditional intensive insulin therapy.
学科主题Cell Biology ; Research & Experimental Medicine
WOS关键词T-CELLS ; AUTOIMMUNE-DISEASES ; MULTIPLE-SCLEROSIS ; TH17 CELLS ; FOLLOW-UP ; CHILDREN ; SUPPRESSION ; MECHANISMS
语种英语
出版者BIOMED CENTRAL LTD
WOS记录号WOS:000399463400011
版本出版稿
源URL[http://202.127.25.144/handle/331004/1149]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Endocrinol & Metab,Shanghai Inst Endocrine &, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China;
2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Endocrine & Metab E Inst Shanghai Univ, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China;
3.Chinese Hlth Minist, Key Lab Endocrinol & Metab, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China;
4.Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Shanghai Inst Immunol, Shanghai, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai, Peoples R China;
6.SJTUSM, Shanghai, Peoples R China;
7.Shanghai Jiao Tong Univ, Chinese Acad Sci, Shanghai Inst Biol Sci, Sch Med,Lab Endocrinol & Metab,Inst Hlth Sci, Shanghai, Peoples R China,
推荐引用方式
GB/T 7714		 Ye, Lei,Li, Li,Yang, Minglan,et al. Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus[J]. STEM CELL RESEARCH & THERAPY,2017,8(-):90.
APA Ye, Lei.,Li, Li.,Yang, Minglan.,Hong, Jie.,Gu, Weiqiong.,...&,.(2017).Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus.STEM CELL RESEARCH & THERAPY,8(-),90.
MLA Ye, Lei,et al."Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus".STEM CELL RESEARCH & THERAPY 8.-(2017):90.

入库方式： OAI收割

来源：上海营养与健康研究所

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