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Identification of a hybrid myocardial zone in the mammalian heart after birth

文献类型：期刊论文

作者Tian, Xueying1,2; Li, Yan1,2; He, Lingjuan1,2; Huang, Xiuzhen1,2; Liu, Qiaozhen1,2; Pu, Wenjuan1,2; Zhang, Libo1,2; Li, Yi1,2; Zhao, Huan1,2; Zhou, Bin1,2,3
刊名NATURE COMMUNICATIONS
出版日期2017
卷号8期号:-页码:87
ISSN号2041-1723
关键词cancer detection liquid biopsy RNA-seq data support vector machine maximum relevance minimum redundancy
DOI10.1038/s41467-017-00118-1
文献子类Article
英文摘要Noncompaction cardiomyopathy is characterized by the presence of extensive trabeculations, which could lead to heart failure and malignant arrhythmias. How trabeculations resolve to form compact myocardium is poorly understood. Elucidation of this process is critical to understanding the pathophysiology of noncompaction disease. Here we use genetic lineage tracing to mark the Nppa(+) or Hey(2+) cardiomyocytes as trabecular and compact components of the ventricular wall. We find that Nppa(+) and Hey(2+) cardiomyocytes, respectively, from the endocardial and epicardial zones of the ventricular wall postnatally. Interposed between these two postnatal layers is a hybrid zone, which is composed of cells derived from both the Nppa(+) and Hey(2+) populations. Inhibition of the fetal Hey(2+) cell contribution to the hybrid zone results in persistence of excessive trabeculations in postnatal heart. Our findings indicate that the expansion of Hey(2+) fetal compact component, and its contribution to the hybrid myocardial zone, are essential for normal formation of the ventricular walls.
学科主题Science & Technology - Other Topics
WOS关键词LEFT-VENTRICULAR NONCOMPACTION ; LINEAGE TRACING REVEALS ; CORONARY-ARTERIES ; CARDIOMYOCYTE PROLIFERATION ; GENE-EXPRESSION ; NON-COMPACTION ; CELLS ; ANGIOGENESIS ; KNOCKOUT ; LIVER
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000405900400004
版本出版稿
源URL[http://202.127.25.144/handle/331004/1150]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,CAS Ctr Excellence Mol Ce, Shanghai 200031, Peoples R China;
2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China;
3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China;
4.Fudan Univ, Huashan Hosp, Dept Neurosurg, State Key Lab Med Neurobiol,Inst Brain Sci, Shanghai 200032, Peoples R China;
5.Fudan Univ, Shanghai Med Coll, Shanghai 200032, Peoples R China;
6.Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China;
7.Peking Union Med Coll, Beijing 100037, Peoples R China;
8.Charles Univ Prague, Fac Med 1, Inst Anat, Prague 12800, Czech Republic;
9.Czech Acad Sci, Inst Physiol, Prague 12800, Czech Republic;
10.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China;
推荐引用方式
GB/T 7714		 Tian, Xueying,Li, Yan,He, Lingjuan,et al. Identification of a hybrid myocardial zone in the mammalian heart after birth[J]. NATURE COMMUNICATIONS,2017,8(-):87.
APA Tian, Xueying.,Li, Yan.,He, Lingjuan.,Huang, Xiuzhen.,Liu, Qiaozhen.,...&,.(2017).Identification of a hybrid myocardial zone in the mammalian heart after birth.NATURE COMMUNICATIONS,8(-),87.
MLA Tian, Xueying,et al."Identification of a hybrid myocardial zone in the mammalian heart after birth".NATURE COMMUNICATIONS 8.-(2017):87.

入库方式： OAI收割

来源：上海营养与健康研究所

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