A single factor dominates the behavior of rhythmic genes in mouse organs
文献类型：期刊论文
| 作者 | Cheng, Yang1; Chi, Yuhao1; Wang, Guang-Zhong1; Zhang, Luoying2; , |
| 刊名 | BMC GENOMICS
 |
| 出版日期 | 2019 |
| 卷号 | 20期号:1页码:879 |
| 关键词 | Circadian rhythm Rhythmically expressed gene Rhythmic gene function Energy cost |
| ISSN号 | 1471-2164 |
| DOI | 10.1186/s12864-019-6255-3 |
| 文献子类 | Article |
| 英文摘要 | Background Circadian rhythm, regulated by both internal and external environment of the body, is a multi-scale biological oscillator of great complexity. On the molecular level, thousands of genes exhibit rhythmic transcription, which is both organ- and species-specific, but it remains a mystery whether some common factors could potentially explain their rhythmicity in different organs. In this study we address this question by analyzing the transcriptome data in 12 mouse organs to determine such major impacting factors. Results We found a strong positive correlation between the transcriptional level and rhythmic amplitude of circadian rhythmic genes in mouse organs. Further, transcriptional level could explain over 70% of the variation in amplitude. In addition, the functionality and tissue specificity were not strong predictors of amplitude, and the expression level of rhythmic genes was linked to the energy consumption associated with transcription. Conclusion Expression level is a single major factor impacts the behavior of rhythmic genes in mouse organs. This single determinant implicates the importance of rhythmic expression itself on the design of the transcriptional system. So, rhythmic regulation of highly expressed genes can effectively reduce the energetic cost of transcription, facilitating the long-term adaptive evolution of the entire genetic system. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | CIRCADIAN-RHYTHMS ; TRANSCRIPTIONAL ARCHITECTURE ; EXPRESSION ; CLOCK ; NETWORKS ; REACTOME ; BIOLOGY ; SLEEP |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31747875 |
| WOS记录号 | WOS:000498637500005 |
| 出版者 | BMC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1151]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Computat Biol,CAS MPG Partner Inst Co, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 2.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Minist Educ, Key Lab Mol Biophys, Wuhan 430074, Hubei, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Cheng, Yang,Chi, Yuhao,Wang, Guang-Zhong,et al. A single factor dominates the behavior of rhythmic genes in mouse organs[J]. BMC GENOMICS,2019,20(1):879. |
| APA | Cheng, Yang,Chi, Yuhao,Wang, Guang-Zhong,Zhang, Luoying,&,.(2019).A single factor dominates the behavior of rhythmic genes in mouse organs.BMC GENOMICS,20(1),879. |
| MLA | Cheng, Yang,et al."A single factor dominates the behavior of rhythmic genes in mouse organs".BMC GENOMICS 20.1(2019):879. |
入库方式： OAI收割
来源：上海营养与健康研究所
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