BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis
文献类型：期刊论文
| 作者 | Yuan, Yan-Mei1; Ma, Ning1; Zhang, Er-Bin1; Chen, Tian-Wei1; Jiang, Hao1; Yin, Fen-Fen1; Wang, Jing-Jing1; Zhang, Feng-Kun1; Ni, Qian-Zhi1; Li, Jing-Jing1 |
| 刊名 | ONCOGENE
 |
| 出版日期 | 2019 |
| 卷号 | 38期号:48页码:7281-7293 |
| 关键词 | Hematopoietic stem cell Type 1 diabetes mellitus Immune response Th1 cell Th17 cell Regulartory T cell |
| ISSN号 | 0950-9232 |
| DOI | 10.1038/s41388-019-0943-y |
| 文献子类 | Article |
| 英文摘要 | Bone morphogenetic protein 10 (BMP10), one member of the BMP family, is involved in various development events. Dysregulation of BMP10 has been observed in several diseases, including hypertensive cardiac hypertrophy, Hirschsprung disease and blood vessel formation. However, its role in liver cancer remains largely unknown. In this study, we reported that BMP10 was significantly downregulated in HCC at both mRNA and protein level. Decreased BMP10 was associated with bigger tumor size, worse TNM stage, earlier recurrence and poorer survival. BMP10 negatively regulated HCC cell proliferation in vitro and in vivo. Mechanism study revealed that BMP10 suppressed tumor cell growth by inhibiting STAT3 signaling. Interestingly, we found that cytoplasmic BMP10 interacted with both receptor protein tyrosine phosphatase sigma (PTPRS) and STAT3, which facilitated dephosphorylation of STAT3 by PTPRS. Altogether, our study has revealed the clinical significance of BMP10 in HCC, and suppression of HCC cell growth by BMP10 via PTPRS-STAT3 axis, providing a potential therapeutic strategy for targeting STAT3 signaling in HCC. |
| 学科主题 | Cell Biology ; Research & Experimental Medicine |
| WOS关键词 | GROWTH-FACTOR ; TUMOR-SUPPRESSOR ; CANCER ; EXPRESSION ; RECEPTOR ; STAT3 ; CELLS ; AGGRESSIVENESS ; IDENTIFICATION ; PROLIFERATION |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31417183 |
| WOS记录号 | WOS:000499631000001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1153]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Nutr & Hlth,CAS Key Lab Nutr Metab, Shanghai 200031, Peoples R China; 2.Huzhou Univ, First Peoples Hosp Affiliated, Key Lab Translat Med, Huzhou 313000, Peoples R China; 3.Huzhou Univ, First Peoples Hosp Affiliated, Dept Surg, Huzhou 313000, Peoples R China; 4.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 6, Shanghai 200438, Peoples R China; 5.Southern Med Univ, Fengxian Hosp, Dept Gen Surg, 6600 Nanfeng Rd, Shanghai 201499, Peoples R China; 6.Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA; 7.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China; 8.China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Beijing 100022, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Yuan, Yan-Mei,Ma, Ning,Zhang, Er-Bin,et al. BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis[J]. ONCOGENE,2019,38(48):7281-7293. |
| APA | Yuan, Yan-Mei.,Ma, Ning.,Zhang, Er-Bin.,Chen, Tian-Wei.,Jiang, Hao.,...&,.(2019).BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis.ONCOGENE,38(48),7281-7293. |
| MLA | Yuan, Yan-Mei,et al."BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis".ONCOGENE 38.48(2019):7281-7293. |
入库方式： OAI收割
来源：上海营养与健康研究所
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