p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms
文献类型：期刊论文
| 作者 | Pitolli, Consuelo1,2; Candi, Eleonora1; Melino, Gerry1,2; Amelio, Ivano1,2; Wang, Ying3; Shi, Yufang3; Candi, Eleonora4; Shi, Yufang5; , |
| 刊名 | CANCERS
 |
| 出版日期 | 2019 |
| 卷号 | 11期号:12页码:1983 |
| ISSN号 | 2211-1247 |
| 关键词 | cell death cancer epigenetics metabolism |
| DOI | 10.3390/cancers11121983 |
| 文献子类 | Review |
| 英文摘要 | The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in mechanisms regulating many other cellular processes, including metabolism, autophagy, and cell migration and invasion, and these pathways might crucially contribute to its tumor suppressor function. In this review we summarize the canonical and non-canonical functions of p53 in an attempt to provide an overview of the potentially crucial aspects related to its tumor suppressor activity. |
| 学科主题 | Cell Biology |
| WOS关键词 | EPITHELIAL-MESENCHYMAL TRANSITION ; GLUTAMINASE 2 ; P53 ; AUTOPHAGY ; FERROPTOSIS ; METABOLISM ; APOPTOSIS ; PROTEIN ; ACTIVATION ; ABSENCE |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31835405 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000507382100160 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1155]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Roma Tor Vergata, Dept Expt Med, TOR, I-00133 Rome, Italy; 2.Univ Cambridge, MRC Toxicol Unit, Cambridge CB2 1QP, England; 3.Chinese Acad Sci, Univ Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Beijing 100012, Peoples R China; 4.IDI IRCCS, Biochem Lab, I-00133 Rome, Italy; 5.Soochow Univ, Inst Translat Med, Suzhou 215006, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Pitolli, Consuelo,Candi, Eleonora,Melino, Gerry,et al. p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms[J]. CANCERS,2019,11(12):1983. |
| APA | Pitolli, Consuelo.,Candi, Eleonora.,Melino, Gerry.,Amelio, Ivano.,Wang, Ying.,...&,.(2019).p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms.CANCERS,11(12),1983. |
| MLA | Pitolli, Consuelo,et al."p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms".CANCERS 11.12(2019):1983. |
入库方式： OAI收割
来源：上海营养与健康研究所
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