DNA methylation aging clocks: challenges and recommendations
文献类型：期刊论文
| 作者 | Bell, Christopher G.2; Lowe, Robert3; Rakyan, Vardhman K.3; Adams, Peter D.1,4,5; Baccarelli, Andrea A.6; Beck, Stephan7; Bell, Jordana T.8; Christensen, Brock C.9,10,11; Gladyshev, Vadim N.12,13; Heijmans, Bastiaan T.14 |
| 刊名 | GENOME BIOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 20期号:1页码:249 |
| ISSN号 | 1474-760X |
| DOI | 10.1186/s13059-019-1824-y |
| 文献子类 | Review |
| 英文摘要 | Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of age-related changes in single-cell, tissue- and disease-specific models, as well as exploring other epigenomic marks, longitudinal and diverse population studies, and non-human models. We also highlight important ethical issues in forensic age determination and predicting the trajectory of biological aging in an individual. |
| 学科主题 | Oncology |
| WOS关键词 | EPIGENETIC AGE ; CLONAL HEMATOPOIESIS ; BIOLOGICAL AGE ; STEM-CELLS ; HISTONE ACETYLATION ; GENOME ARCHITECTURE ; GENE-EXPRESSION ; CANCER-RISK ; LIFE-SPAN ; BLOOD |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31767039 |
| WOS记录号 | WOS:000511880800001 |
| 出版者 | BMC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1156]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Glasgow, Glasgow, Lanark, Scotland; 2.Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England; 3.Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England; 4.Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA 92037 USA; 5.Beatson Inst Canc Res, Glasgow, Lanark, Scotland; 6.Columbia Univ, Dept Environm Hlth Sci, Mailman Sch Publ Hlth, New York, NY 10027 USA; 7.UCL, UCL Canc Inst, Med Genom, Paul OGorman Bldg, London, England; 8.Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England; 9.Dartmouth Coll, Dept Epidemiol, Geisel Sch Med, 1 Med Ctr Dr, Lebanon, NH 03756 USA; 10.Dartmouth Coll, Dept Mol & Syst Biol, Geisel Sch Med, 1 Med Ctr Dr, Lebanon, NH 03756 USA; |
| 推荐引用方式 GB/T 7714 | Bell, Christopher G.,Lowe, Robert,Rakyan, Vardhman K.,et al. DNA methylation aging clocks: challenges and recommendations[J]. GENOME BIOLOGY,2019,20(1):249. |
| APA | Bell, Christopher G..,Lowe, Robert.,Rakyan, Vardhman K..,Adams, Peter D..,Baccarelli, Andrea A..,...&,.(2019).DNA methylation aging clocks: challenges and recommendations.GENOME BIOLOGY,20(1),249. |
| MLA | Bell, Christopher G.,et al."DNA methylation aging clocks: challenges and recommendations".GENOME BIOLOGY 20.1(2019):249. |
入库方式： OAI收割
来源：上海营养与健康研究所
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