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Do Mutations Turn p53 into an Oncogene?

文献类型：期刊论文

作者Pitolli, Consuelo1,2; Mancini, Mara1; Melino, Gerry1,2; Amelio, Ivano1,2; Wang, Ying3; Shi, Yufang3; Mancini, Mara4; Shi, Yufang5; ,
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
出版日期2019
卷号20期号:24页码:6241
关键词TP53 mutant TP53 gain of function oncogenic
ISSN号0092-8674
DOI10.3390/ijms20246241
文献子类Review
英文摘要The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53, but also equip the protein with new pro-oncogenic functions. Here, we review the mechanisms by which these new functions gained by p53 mutants promote tumorigenesis.
学科主题Biochemistry & Molecular Biology ; Cell Biology
WOS关键词GAIN-OF-FUNCTION ; WILD-TYPE P53 ; TUMOR-SUPPRESSOR P53 ; FUNCTION MUTANT P53 ; BREAST-CANCER ; DRUG-RESISTANCE ; GENE-MUTATIONS ; MOUSE MODELS ; DNA-REPAIR ; IN-VIVO
语种英语
CSCD记录号CSCD:31835684
WOS记录号WOS:000506840100135
出版者MDPI
版本出版稿
源URL[http://202.127.25.144/handle/331004/1157]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Univ Roma Tor Vergata, TOR, Dept Expt Med, I-00133 Rome, Italy;
2.Univ Cambridge, MRC Toxicol Unit, Pathology Bldg,Tennis Court Rd, Cambridge CB2 1PQ, England;
3.Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor, Inst Nutr & Hlth, Univ Chinese Acad Sci, Shanghai 100012, Peoples R China;
4.IDI IRCCS, Biochem Lab, I-00167 Rome, Italy;
5.Soochow Univ, Inst Translat Med, Suzhou 215006, Peoples R China,
推荐引用方式
GB/T 7714		 Pitolli, Consuelo,Mancini, Mara,Melino, Gerry,et al. Do Mutations Turn p53 into an Oncogene?[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2019,20(24):6241.
APA Pitolli, Consuelo.,Mancini, Mara.,Melino, Gerry.,Amelio, Ivano.,Wang, Ying.,...&,.(2019).Do Mutations Turn p53 into an Oncogene?.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,20(24),6241.
MLA Pitolli, Consuelo,et al."Do Mutations Turn p53 into an Oncogene?".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20.24(2019):6241.

入库方式： OAI收割

来源：上海营养与健康研究所

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