PTEN alpha and PTEN beta promote carcinogenesis through WDR5 and H3K4 trimethylation
文献类型：期刊论文
| 作者 | Shen, Shao-Ming1,2; Zhang, Cheng1,2; Ge, Meng-Kai1,2; Xia, Li1,2; He, Ping1,2; Zhang, Na1,2; Yang, Shuo1,2; Yu, Yun1,2; Zheng, Jun-Ke1,2; Chen, Guo-Qiang1,2 |
| 刊名 | NATURE CELL BIOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 21期号:11页码:1436+ |
| 关键词 | Alu back-splicing circRNA complementary sequence evolution SINE species-specific |
| ISSN号 | 1465-7392 |
| DOI | 10.1038/s41556-019-0409-z |
| 文献子类 | Article |
| 英文摘要 | PTEN alpha and PTEN beta are two longer translational variants of phosphatase and tensin homolog (PTEN) messenger RNA. Their expressional regulations and functions in carcinogenesis remain largely unknown. Here, we demonstrate that, in contrast with the well-established tumour-suppressive role of canonical PTEN, PTEN alpha and PTEN beta promote tumourigenesis by directly interacting with the histone H3 lysine 4 (H3K4) presenter WDR5 to promote H3K4 trimethylation and maintain a tumour-promoting signature. We also show that USP9X and FBXW11 bind to the amino-terminal extensions of PTEN alpha/beta, and respectively deubiquitinate and ubiquitinate lysines 235 and 239 in PTEN alpha to regulate PTEN alpha/beta stability. In accordance, USP9X promotes tumourigenesis and FBXW11 suppresses tumourigenesis through PTEN alpha/beta. Taken together, our results indicate that the Pten gene is a double-edged sword for carcinogenesis, and reinterpretation of the importance of the Pten gene in carcinogenesis is warranted. |
| 学科主题 | Biochemistry & Molecular Biology |
| WOS关键词 | NOTCH3 ; USP9X ; EXPRESSION ; CELLS ; METHYLATION ; PHOSPHATASE ; PATHWAY ; DRIVES |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31685992 |
| WOS记录号 | WOS:000495888300015 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1159]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Ren Ji Hosp, Dept Pathophysiol,Sch Med,Shanghai Canc Inst, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Chinese Minist Educ, Key Lab Cell Differentiat & Apoptosis, Sch Med, Shanghai, Peoples R China; 3.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Tumor Microenvironm & Inflammat, Dept Biochem & Mol Cell Biol, Shanghai, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Dept Liver Surg, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Shen, Shao-Ming,Zhang, Cheng,Ge, Meng-Kai,et al. PTEN alpha and PTEN beta promote carcinogenesis through WDR5 and H3K4 trimethylation[J]. NATURE CELL BIOLOGY,2019,21(11):1436+. |
| APA | Shen, Shao-Ming.,Zhang, Cheng.,Ge, Meng-Kai.,Xia, Li.,He, Ping.,...&,.(2019).PTEN alpha and PTEN beta promote carcinogenesis through WDR5 and H3K4 trimethylation.NATURE CELL BIOLOGY,21(11),1436+. |
| MLA | Shen, Shao-Ming,et al."PTEN alpha and PTEN beta promote carcinogenesis through WDR5 and H3K4 trimethylation".NATURE CELL BIOLOGY 21.11(2019):1436+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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