Cell and tissue type independent age-associated DNA methylation changes are not rare but common
文献类型：期刊论文
| 作者 | Zhu, Tianyu1; Zheng, Shijie C.1; Teschendorff, Andrew E.1; Paul, Dirk S.2; Horvath, Steve3,4; Teschendorff, Andrew E.5; , |
| 刊名 | AGING-US
 |
| 出版日期 | 2018 |
| 卷号 | 10期号:11页码:3541-3557 |
| 关键词 | DNA methylation epigenetic drift epigenetic clock |
| ISSN号 | 1945-4589 |
| DOI | 10.18632/aging.101666 |
| 文献子类 | Article |
| 英文摘要 | Age-associated DNA methylation changes have been widely reported across many different tissue and cell types. Epigenetic 'clocks' that can predict chronological age with a surprisingly high degree of accuracy appear to do so independently of tissue and cell-type, suggesting that a component of epigenetic drift is cell-type independent. However, the relative amount of age-associated DNAm changes that are specific to a cell or tissue type versus the amount that occurs independently of cell or tissue type is unclear and a matter of debate, with a recent study concluding that most epigenetic drift is tissue-specific. Here, we perform a novel comprehensive statistical analysis, including matched multi cell-type and multi-tissue DNA methylation profiles from the same individuals and adjusting for cell-type heterogeneity, demonstrating that a substantial amount of epigenetic drift, possibly over 70%, is shared between significant numbers of different tissue/cell types. We further show that ELOVL2 is not unique and that many other CpG sites, some mapping to genes in the Wnt and glutamate receptor signaling pathways, are altered with age across at least 10 different cell/tissue types. We propose that while most age-associated DNAm changes are shared between cell-types that the putative functional effect is likely to be tissue-specific. |
| 学科主题 | Cell Biology ; Geriatrics & Gerontology |
| WOS关键词 | WIDESPREAD ; CANCER ; GENES ; RISK ; BIAS |
| 语种 | 英语 |
| WOS记录号 | WOS:000451853300043 |
| 出版者 | IMPACT JOURNALS LLC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1164]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol,Univ Chinese A, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 2.Univ Cambridge, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England; 3.Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA; 4.Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90095 USA; 5.UCL, UCL Canc Inst, Paul OGorman Bldg, London WC1E 6BT, England, |
| 推荐引用方式 GB/T 7714 | Zhu, Tianyu,Zheng, Shijie C.,Teschendorff, Andrew E.,et al. Cell and tissue type independent age-associated DNA methylation changes are not rare but common[J]. AGING-US,2018,10(11):3541-3557. |
| APA | Zhu, Tianyu.,Zheng, Shijie C..,Teschendorff, Andrew E..,Paul, Dirk S..,Horvath, Steve.,...&,.(2018).Cell and tissue type independent age-associated DNA methylation changes are not rare but common.AGING-US,10(11),3541-3557. |
| MLA | Zhu, Tianyu,et al."Cell and tissue type independent age-associated DNA methylation changes are not rare but common".AGING-US 10.11(2018):3541-3557. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。