3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis
文献类型：期刊论文
| 作者 | Ke, Yuwen2,4; Chen, Xuepeng2,4; Liu, Zhenbo2; Sun, Yaoyu2,4; Yao, Xuelong2,4; Li, Fangzhen2; Zhu, Wei2,4; Gao, Lei2; Xu, Xiaocui2,4; Liu, Jiang2,4 |
| 刊名 | CELL
 |
| 出版日期 | 2017 |
| 卷号 | 170期号:2页码:367-+ |
| 关键词 | Gluconeogenesis Temperature Organ crosstalk |
| ISSN号 | 0092-8674 |
| DOI | 10.1016/j.cell.2017.06.029 |
| 文献子类 | Article |
| 英文摘要 | High-order chromatin structure plays important roles in gene expression regulation. Knowledge of the dynamics of 3D chromatin structures during mammalian embryo development remains limited. We report the 3D chromatin architecture of mouse gametes and early embryos using an optimized Hi-C method with low-cell samples. We find that mature oocytes at the metaphase II stage do not have topologically associated domains (TADs). In sperm, extra-long-range interactions (>4 Mb) and interchromosomal interactions occur frequently. The high-order structures of both the paternal and maternal genomes in zygotes and two-cell embryos are obscure but are gradually re-established through development. The establishment of the TAD structure requires DNA replication but not zygotic genome activation. Furthermore, unmethylated CpGs are enriched in A compartment, and methylation levels are decreased to a greater extent in A compartment than in B compartment in embryos. In summary, the global reprogramming of chromatin architecture occurs during early mammalian development. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS关键词 | PREIMPLANTATION EMBRYOS ; REGULATORY LANDSCAPE ; TOPOLOGICAL DOMAINS ; HUMAN GENOME ; STEM-CELLS ; ORGANIZATION ; MOUSE ; GENE ; ARCHITECTURE ; SPERM |
| 语种 | 英语 |
| WOS记录号 | WOS:000405493900015 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1165]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China; 2.Chinese Acad Sci, Beijing Inst Genom, Collaborat Innovat Ctr Genet & Dev, CAS Key Lab Genome Sci & Informat, Beijing, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 4.Univ Chinese Acad Sci, Beijing, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China; 6.Tsinghua Univ, Sch Life Sci, Ctr Stem Cell Biol & Regenerat Med, MOE Key Lab Bioinformat,THU PKU Ctr Life Sci, Beijing, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Ke, Yuwen,Chen, Xuepeng,Liu, Zhenbo,et al. 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis[J]. CELL,2017,170(2):367-+. |
| APA | Ke, Yuwen.,Chen, Xuepeng.,Liu, Zhenbo.,Sun, Yaoyu.,Yao, Xuelong.,...&,.(2017).3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis.CELL,170(2),367-+. |
| MLA | Ke, Yuwen,et al."3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis".CELL 170.2(2017):367-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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