A class of circadian long non-coding RNAs mark enhancers modulating long-range circadian gene regulation
文献类型：期刊论文
| 作者 | Fan, Zenghua2,3; Xu, Yichi2,3; Zhao, Meng4; Guo, Weimin4; Wang, Haifang4; Yan, Jun4; Joshi, Parth D.5; Li, Ping1; Zhang, Yan1; Zhao, Zhihu1 |
| 刊名 | NUCLEIC ACIDS RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 45期号:10页码:5720-5738 |
| 关键词 | interleukin-17 mesenchymal stem cells polarization new bone formation ankylosing spondylitis |
| ISSN号 | 0305-1048 |
| DOI | 10.1093/nar/gkx156 |
| 文献子类 | Article |
| 英文摘要 | Circadian rhythm exerts its influence on animal physiology and behavior by regulating gene expression at various levels. Here we systematically explored circadian long non-coding RNAs (lncRNAs) in mouse liver and examined their circadian regulation. We found that a significant proportion of circadian lncRNAs are expressed at enhancer regions, mostly bound by two key circadian transcription factors, BMAL1 and REV-ERB alpha. These circadian lncRNAs showed similar circadian phases with their nearby genes. The extent of their nuclear localization is higher than protein coding genes but less than enhancer RNAs. The association between enhancer and circadian lncRNAs is also observed in tissues other than liver. Comparative analysis between mouse and rat circadian liver transcriptomes showed that circadian transcription at lncRNA loci tends to be conserved despite of low sequence conservation of lncRNAs. One such circadian lncRNA termed lnc-Crot led us to identify a super-enhancer region interacting with a cluster of genes involved in circadian regulation of metabolism through long-range interactions. Further experiments showed that lnc-Crot locus has enhancer function independent of lnc-Crot's transcription. Our results suggest that the enhancer-associated circadian lncRNAs mark the genomic loci modulating long-range circadian gene regulation and shed new lights on the evolutionary origin of lncRNAs. |
| 学科主题 | Biochemistry & Molecular Biology |
| WOS关键词 | REV-ERB-ALPHA ; EXPRESSION ATLAS ; LIPID-METABOLISM ; SUPER-ENHANCERS ; TRANSCRIPTION ; CLOCK ; GENOME ; MOUSE ; EVOLUTION ; REVEALS |
| 语种 | 英语 |
| WOS记录号 | WOS:000402510700025 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1168]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Beijing Inst Biotechnol, 20 Dongdajie St, Beijing 100071, Peoples R China, 2.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; 4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai Inst Biol Sci, Inst Neurosci,State Key Lab Neurosci, Shanghai 200031, Peoples R China; 5.Max Planck Inst Biophys Chem, Dept Genes & Behav, Fassberg 11, D-37077 Gottingen, Germany; |
| 推荐引用方式 GB/T 7714 | Fan, Zenghua,Xu, Yichi,Zhao, Meng,et al. A class of circadian long non-coding RNAs mark enhancers modulating long-range circadian gene regulation[J]. NUCLEIC ACIDS RESEARCH,2017,45(10):5720-5738. |
| APA | Fan, Zenghua.,Xu, Yichi.,Zhao, Meng.,Guo, Weimin.,Wang, Haifang.,...&,.(2017).A class of circadian long non-coding RNAs mark enhancers modulating long-range circadian gene regulation.NUCLEIC ACIDS RESEARCH,45(10),5720-5738. |
| MLA | Fan, Zenghua,et al."A class of circadian long non-coding RNAs mark enhancers modulating long-range circadian gene regulation".NUCLEIC ACIDS RESEARCH 45.10(2017):5720-5738. |
入库方式： OAI收割
来源：上海营养与健康研究所
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