中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海营养与健康研究所
  3. 中国科学院上海生命科学研究院营养科学研究所
LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis

文献类型：期刊论文

作者Wang, Dan2,3; Hou, Lei2; Su, Ming2; Li, Fang2; Chen, Weiyang2; Yan, Yizhen2,3; Green, Christopher D.2; Han, Jing-Dong J.2; Nakamura, Shuhei1; Antebi, Adam1
刊名AGING CELL
出版日期2017
卷号16期号:1页码:113-124
ISSN号1474-9718
关键词Caenorhabditis elegans DAF-16 let-7 LIN-28 longevity reproduction
DOI10.1111/acel.12539
文献子类Article
英文摘要The RNA-binding protein LIN-28 was first found to control developmental timing in Caenorhabditis elegans. Later, it was found to play important roles in pluripotency, metabolism, and cancer in mammals. Here we report that a low dosage of lin-28 enhanced stress tolerance and longevity, and reduced germline stem/progenitor cell number in C. elegans. The germline LIN-28-regulated microRNA let-7 was required for these effects by targeting akt-1/2 and decreasing their protein levels. AKT-1/2 and the downstream DAF-16 transcription factor were both required for the lifespan and germline stem cell effects of lin-28. The pathway also mediated dietary restriction induced lifespan extension and reduction in germline stem cell number. Thus, the LIN-28/let-7/AKT/DAF-16 axis we delineated here is a program that plays an important role in balancing reproduction and somatic maintenance and their response to the environmental energy level-a central dogma of the 'evolutionary optimization' of resource allocation that modulates aging.
学科主题Cell Biology ; Geriatrics & Gerontology
WOS关键词LIFE-SPAN ; C. ELEGANS ; IN-VIVO ; MICRORNA ; LET-7 ; RNA ; LIN28 ; EXPRESSION ; METABOLISM ; TRANSLATION
语种英语
出版者WILEY-BLACKWELL
WOS记录号WOS:000392287700011
版本出版稿
源URL[http://202.127.25.144/handle/331004/1176]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Max Planck Inst Biol Ageing, Joseph Stelzmann Str 9b, D-50931 Cologne, Germany;
2.Chinese Acad Sci, Max Planck Partner Inst Computat Biol, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, Key Lab Computat Biol,Collaborat Innovat Ctr Gene, 320 Yue Yang Rd, Shanghai 200031, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
4.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Model Anim Res Ctr, Nanjing 210061, Jiangsu, Peoples R China;
5.Nanjing Univ, MOE Key Lab Model Anim Dis Study, Model Anim Res Ctr, Nanjing 210061, Jiangsu, Peoples R China;
6.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China,
推荐引用方式
GB/T 7714		 Wang, Dan,Hou, Lei,Su, Ming,et al. LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis[J]. AGING CELL,2017,16(1):113-124.
APA Wang, Dan.,Hou, Lei.,Su, Ming.,Li, Fang.,Chen, Weiyang.,...&,.(2017).LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis.AGING CELL,16(1),113-124.
MLA Wang, Dan,et al."LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis".AGING CELL 16.1(2017):113-124.

入库方式： OAI收割

来源：上海营养与健康研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。