YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
文献类型：期刊论文
| 作者 | Shi, Yulin1,2; Jiang, Liping1; Shen, Qiushuo1,2; Xu, Peifang1; Zeng, Lin1,2; Zhou, Jumin1; Yang, Cuiping1; Chen, Yongbin1,9; Fan, Songqing3; Wu, Mengge4 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2019 |
| 卷号 | 10期号:-页码:4892 |
| 关键词 | HSP90 beta lipid metabolism corylin SREBPs proteasomal degradation |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-019-12801-6 |
| 文献子类 | Article |
| 英文摘要 | Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here, we report that genes involved in various human cancers evolved rapidly in Tibetans and six Tibetan domestic mammals compared to reciprocal lowlanders. Furthermore, m(6)A modified mRNA binding protein YTHDF1, one of evolutionary positively selected genes for high-altitude adaptation is amplified in various cancers, including non-small cell lung cancer (NSCLC). We show that YTHDF1 deficiency inhibits NSCLC cell proliferation and xenograft tumor formation through regulating the translational efficiency of CDK2, CDK4, and cyclin D1, and that YTHDF1 depletion restrains de novo lung adenocarcinomas (ADC) progression. However, we observe that YTHDF1 high expression correlates with better clinical outcome, with its depletion rendering cancerous cells resistant to cisplatin (DDP) treatment. Mechanistic studies identified the Keap1-Nrf2-AKR1C1 axis as the downstream mediator of YTHDF1. Together, these findings highlight the critical role of YTHDF1 in both hypoxia adaptation and pathogenesis of NSCLC. |
| 学科主题 | Chemistry |
| WOS关键词 | MESSENGER-RNA ; RESISTANCE ; ANGIOGENESIS ; TRANSLATION ; PLASTICITY ; SELECTION ; IMPACT ; NRF2 ; ROS |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31653849 |
| WOS记录号 | WOS:000492835100030 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1178]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China; 2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China; 3.Cent S Univ, Second Xiangya Hosp, Dept Pathol, Changsha 410000, Hunan, Peoples R China; 4.Kunming Med Univ, Kunming 650223, Yunnan, Peoples R China; 5.Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 7.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 8.Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Key Lab Computat Biol, Shanghai 200031, Peoples R China; 9.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China; 10.Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Shi, Yulin,Jiang, Liping,Shen, Qiushuo,et al. YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression[J]. NATURE COMMUNICATIONS,2019,10(-):4892. |
| APA | Shi, Yulin.,Jiang, Liping.,Shen, Qiushuo.,Xu, Peifang.,Zeng, Lin.,...&,.(2019).YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.NATURE COMMUNICATIONS,10(-),4892. |
| MLA | Shi, Yulin,et al."YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression".NATURE COMMUNICATIONS 10.-(2019):4892. |
入库方式： OAI收割
来源：上海营养与健康研究所
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