TAF1 plays a critical role in AML1-ETO driven leukemogenesis
文献类型：期刊论文
| 作者 | Xu, Ye1,2; Man, Na1; Karl, Daniel1,3; Martinez, Concepcion1,3; Liu, Fan1,3; Sun, Jun1,3; Martinez, Camilo Jose1,3; Martin, Gloria Mas1,3; Beckedorff, Felipe1; Lai, Fan1,4 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2019 |
| 卷号 | 10期号:-页码:4925 |
| 关键词 | Osteoglycin Angiogenesis Extracellular matrix VEGF VEGFR2 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-019-12735-z |
| 文献子类 | Article |
| 英文摘要 | AML1-ETO (AE) is a fusion transcription factor, generated by the t(8;21) translocation, that functions as a leukemia promoting oncogene. Here, we demonstrate that TATA-Box Binding Protein Associated Factor 1 (TAF1) associates with K43 acetylated AE and this association plays a pivotal role in the proliferation of AE-expressing acute myeloid leukemia (AML) cells. ChIP-sequencing indicates significant overlap of the TAF1 and AE binding sites. Knockdown of TAF1 alters the association of AE with chromatin, affecting of the expression of genes that are activated or repressed by AE. Furthermore, TAF1 is required for leukemic cell self-renewal and its reduction promotes the differentiation and apoptosis of AE+ AML cells, thereby impairing AE driven leukemogenesis. Together, our findings reveal a role of TAF1 in leukemogenesis and identify TAF1 as a potential therapeutic target for AE-expressing leukemia. |
| 学科主题 | Cardiovascular System & Cardiology |
| WOS关键词 | ACUTE-LEUKEMIA ; FUSION PROTEIN ; C/EBP-ALPHA ; TRANSCRIPTION ; T(8/21) ; T(8-21) ; COMPLEX ; EXPRESSION ; SUBUNIT ; TARGET |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31664040 |
| WOS记录号 | WOS:000493042500015 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1180]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Miami, Sylvester Comprehens Canc Ctr, 1120 NW 14th St, Miami, FL 33136 USA; 2.Univ Miami, Miller Sch Med, Dept Med, 1120 NW 14th St, Miami, FL 33136 USA; 3.Univ Miami, Miller Sch Med, Dept Biochem & Mol Biol, 1501 NW 10th Ave, Miami, FL 33136 USA; 4.Univ Miami, Miller Sch Med, Dept Human Genet, 1120 NW 14th St, Miami, FL 33136 USA; 5.Shanghai Jiao Tong Univ, Sch Med, Chinese Acad Sci, Inst Hlth Sci,Shanghai Inst Biol Sci, Shanghai, Peoples R China; 6.Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, State Key Lab Med Gen,Shanghai Inst Hematol, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Xu, Ye,Man, Na,Karl, Daniel,et al. TAF1 plays a critical role in AML1-ETO driven leukemogenesis[J]. NATURE COMMUNICATIONS,2019,10(-):4925. |
| APA | Xu, Ye.,Man, Na.,Karl, Daniel.,Martinez, Concepcion.,Liu, Fan.,...&,.(2019).TAF1 plays a critical role in AML1-ETO driven leukemogenesis.NATURE COMMUNICATIONS,10(-),4925. |
| MLA | Xu, Ye,et al."TAF1 plays a critical role in AML1-ETO driven leukemogenesis".NATURE COMMUNICATIONS 10.-(2019):4925. |
入库方式： OAI收割
来源：上海营养与健康研究所
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