Gp130 degradation induced by epirubicin contributes to chemotherapy efficacy
文献类型：期刊论文
| 作者 | Liu, Fangming1; Tian, Ye1; Jin, Haizhen2; Wu, Dan2; Huang, Chao3; Shen, Jinhong4; , |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2019 |
| 卷号 | 519期号:3页码:572-578 |
| 关键词 | Epirubicin gp130 Phosphorylation Autophagy p38 Lung cancer |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2019.09.055 |
| 文献子类 | Article |
| 英文摘要 | Two anthracyclines, doxorubicin and epirubicin have been widely used alone or in combination with other antitumor reagents in the chemotherapeutic treatment of various malignancies. Although therapeutic efficacy of anthracyclines has been studied extensively, precise cytotoxic mechanism of these drugs is not been completely elucidated. Here we show that epirubicin-induced degradation of transmembrane protein gp130 contributes to antitumor effect of epirubicin. gp130 is degraded by epirubicin in a proteasome- and autophagy-dependent manner. Epirubicin induces activation of p38-MK2 signaling pathway to phosphorylate gp130 at Ser 782, which results in gp130 internalization and degradation by lysosome. Although mutation of Ser 782 to Ala or Cys in gp130 upregulates global epirubicin-induced autophagy, reduced degradation of gp130 accompanied with enhanced Stat3 phosphorylation at tyrosine 705 is observed. We also show that epirubicin-resistant tumor cells express higher level of gp130. Altogether, our results indicate that degradation of gp130 and subsequent reduction of gp130-Stat3 signaling contributes to epirubicin-induced tumor cell death. (C) 2019 Elsevier Inc. All rights reserved. |
| 学科主题 | Oncology ; Cell Biology |
| WOS关键词 | CELL LUNG-CANCER ; LYSOSOMAL DEGRADATION ; STAT3 ACTIVATION ; AUTOPHAGY ; INTERNALIZATION ; DOXORUBICIN ; RESISTANCE ; ASSOCIATION ; INHIBITION ; EXPRESSION |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31537377 |
| WOS记录号 | WOS:000506407800019 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1181]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing 100050, Peoples R China; 2.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Cent Lab, Shanghai 200025, Peoples R China; 3.Shanghai Jiao Tong Univ, Thorac Oncol Inst, Shanghai Chest Hosp, Sch Med, Shanghai 200025, Peoples R China; 4.Jiaotong Univ, Inst Hlth Sci, Chinese Acad Sci, Sch Med, 320 Yueyang Rd, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Liu, Fangming,Tian, Ye,Jin, Haizhen,et al. Gp130 degradation induced by epirubicin contributes to chemotherapy efficacy[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2019,519(3):572-578. |
| APA | Liu, Fangming.,Tian, Ye.,Jin, Haizhen.,Wu, Dan.,Huang, Chao.,...&,.(2019).Gp130 degradation induced by epirubicin contributes to chemotherapy efficacy.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,519(3),572-578. |
| MLA | Liu, Fangming,et al."Gp130 degradation induced by epirubicin contributes to chemotherapy efficacy".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 519.3(2019):572-578. |
入库方式： OAI收割
来源：上海营养与健康研究所
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