Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs
文献类型：期刊论文
| 作者 | Wang, Ying1; Xiong, Yi-Chun1; Wei, Jia1; Yang, Li1,2; Gao, Runze2,3,4; Wu, Jing2; Zhang, Sipin2; Chen, Jia2,3; Yang, Bei5; , |
| 刊名 | GENOME BIOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 20期号:1页码:218 |
| ISSN号 | 1474-760X |
| 关键词 | Base editing Base editor CRISPR Cas Cytidine deaminase Pathogenic mutation |
| DOI | 10.1186/s13059-019-1839-4 |
| 文献子类 | Article |
| 英文摘要 | A variety of base editors have been developed to achieve C-to-T editing in different genomic contexts. Here, we compare a panel of five base editors on their C-to-T editing efficiencies and product purity at commonly editable sites, including some human pathogenic C-to-T mutations. We further profile the accessibilities of 20 base editors to all possible pathogenic mutations in silico. Finally, we build the BEable-GPS (Base Editable prediction of Global Pathogenic SNVs) database for users to select proper base editors to model or correct disease-related mutations. The in vivo comparison and in silico profiling catalog the availability of base editors and their broad applications in biomedical studies. |
| 学科主题 | Cell Biology |
| WOS关键词 | DNA ; APOBEC |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31647030 |
| 出版者 | BMC |
| WOS记录号 | WOS:000492309200001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1182]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Chinese Acad Sci,Shanghai Inst Biol Sci, CAS Key Lab Computat Biol,CAS MPG Partner Inst Co, Shanghai 200031, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 3.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 5.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Wang, Ying,Xiong, Yi-Chun,Wei, Jia,et al. Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs[J]. GENOME BIOLOGY,2019,20(1):218. |
| APA | Wang, Ying.,Xiong, Yi-Chun.,Wei, Jia.,Yang, Li.,Gao, Runze.,...&,.(2019).Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs.GENOME BIOLOGY,20(1),218. |
| MLA | Wang, Ying,et al."Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs".GENOME BIOLOGY 20.1(2019):218. |
入库方式： OAI收割
来源：上海营养与健康研究所
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