Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas
文献类型：期刊论文
| 作者 | Pan, XiaoYong1,2,3; Zhu, LiuCun1; Wan, SiBao1; Cal, Yu-Dong1; Zeng, Tao4; Yuan, Fei5; Zhang, Yu-Hang6; Huang, Tao6; Chen, Lei7,8; , |
| 刊名 | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 7期号:-页码:339 |
| 关键词 | isocitrate dehydrogenase methylation IDH-mutation gliomas multi-class classification |
| ISSN号 | 2296-4185 |
| DOI | 10.3389/fbioe.2019.00339 |
| 文献子类 | Article |
| 英文摘要 | Isocitrate dehydrogenase (IDH) is an oncogene, and the expression of a mutated IDH promotes cell proliferation and inhibits cell differentiation. IDH exists in three different isoforms, whose mutation can cause many solid tumors, especially gliomas in adults. No effective method for classifying gliomas on genetic signatures is currently available. DNA methylation may be applied to distinguish cancer cells from normal tissues. In this study, we focused on three subtypes of IDH-mutation gliomas by examining methylation data. Several advanced computational methods were used, such as Monte Carlo feature selection (MCFS), incremental feature selection (IFS), support machine vector (SVM), etc. The MCFS method was adopted to analyze methylation features, resulting in a feature list. Then, the IFS method incorporating SVM was applied to the list to extract important methylation features and construct an optimal SVM classifier. As a result, several methylation features (sites) were found to relate to glioma subclasses, which are annotated onto multiple genes, such as FLJ37543, LCE3D, FAM89A, ADCY5, ESR1, C2orf67, REST, EPHA7, etc. These genes are enriched in biological functions, including cellular developmental process, neuron differentiation, cellular component morphogenesis, and G-protein-coupled receptor signaling pathway. Our results, which are supported by literature reports and independent dataset validation, showed that our identified genes and functions contributed to the detailed glioma subtypes. This study provided a basic research on IDH-mutation gliomas. |
| 学科主题 | Nutrition & Dietetics |
| WOS关键词 | CIRCULATING IMMUNE-COMPLEXES ; CARLO FEATURE-SELECTION ; NEURAL STEM-CELLS ; DNA METHYLATION ; CDNA MICROARRAY ; EXPRESSION ; IDENTIFICATION ; PROFILES ; ANTIGENS ; WNT |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31803734 |
| WOS记录号 | WOS:000499428900001 |
| 出版者 | FRONTIERS MEDIA SA |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1183]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Inst Image Proc & Pattern Recognit, Minist Educ China, Key Lab Syst Control & Informat Proc, Shanghai, Peoples R China; 3.Univ Ghent, Dept Elect & Informat Syst, IDLab, Ghent, Belgium; 4.Chinese Acad Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai, Peoples R China; 5.Binzhou Med Univ Hosp, Dept Sci & Technol, Binzhou, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China; 7.Shanghai Maritime Univ, Coll Informat Engn, Shanghai, Peoples R China; 8.East China Normal Univ, Shanghai Key Lab PMMP, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Pan, XiaoYong,Zhu, LiuCun,Wan, SiBao,et al. Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2019,7(-):339. |
| APA | Pan, XiaoYong.,Zhu, LiuCun.,Wan, SiBao.,Cal, Yu-Dong.,Zeng, Tao.,...&,.(2019).Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,7(-),339. |
| MLA | Pan, XiaoYong,et al."Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 7.-(2019):339. |
入库方式： OAI收割
来源：上海营养与健康研究所
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