An update on lipid oxidation and inflammation in cardiovascular diseases
文献类型：期刊论文
| 作者 | Zhong, Shanshan1; Li, Luxiao1; Shen, Xia1; Tao, Yongzhen1; Yin, Huiyong1,2; Shen, Xia2; Li, Qiujing3; Wang, Xiaoping3; Xu, Wenxin4; Yin, Huiyong5 |
| 刊名 | FREE RADICAL BIOLOGY AND MEDICINE
 |
| 出版日期 | 2019 |
| 卷号 | 144期号:SI页码:266-278 |
| ISSN号 | 0891-5849 |
| 关键词 | Lipid peroxidation Cardiovascular disease Atherosclerosis Low density lipoprotein (LDL) Macrophages Inflammation Lipoprotein (a) Lipidomics |
| DOI | 10.1016/j.freeradbiomed.2019.03.036 |
| 文献子类 | Review |
| 英文摘要 | Cardiovascular diseases (CVD), including ischemic heart diseases and cerebrovascular diseases, are the leading causes of morbidity and mortality worldwide. Atherosclerosis is the major underlying factor for most CVD. It is well-established that oxidative stress and inflammation are two major mechanisms leading to atherosclerosis. Under oxidative stress, polyunsaturated fatty acids (PUFA)-containing phospholipids and cholesterol esters in cellular membrane and lipoproteins can be readily oxidized through a free radical-induced lipid peroxidation (LPO) process to form a complex mixture of oxidation products. Overwhelming evidence demonstrates that these oxidized lipids are actively involved in the inflammatory responses in atherosclerosis by interacting with immune cells (such as macrophages) and endothelial cells. In addition to lipid lowering in the prevention and treatment of atherosclerotic CVD, targeting chronic inflammation has been entering the medical realm. Clinical trials are under way to lower the lipoprotein (a) (Lp(a)) and its associated oxidized phospholipids, which will provide clinical evidence that targeting inflammation caused by oxidized lipids is a viable approach for CVD. In this review, we aim to give an update on our understanding of the free radical oxidation of LPO, analytical technique to analyze the oxidation products, especially the oxidized phospholipids and cholesterol esters in low density lipoproteins (LDL), and focusing on the experimental and clinical evidence on the role of lipid oxidation in the inflammatory responses associated with CVD, including myocardial infarction and calcific aortic valve stenosis. The challenges and future directions in understanding the role of LPO in CVD will also be discussed. |
| 学科主题 | Gastroenterology & Hepatology |
| WOS关键词 | LOW-DENSITY-LIPOPROTEIN ; OXIDIZED CHOLESTERYL ESTERS ; IN-VIVO ; STRUCTURAL IDENTIFICATION ; 4-HYDROXYNONENAL 4-HNE ; PERCUTANEOUS CORONARY ; GLOBAL BURDEN ; LIPOXIN A(4) ; RISK-FACTORS ; PHOSPHOLIPIDS |
| 语种 | 英语 |
| CSCD记录号 | CSCD:30946962 |
| 出版者 | ELSEVIER SCIENCE INC |
| WOS记录号 | WOS:000493943700023 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1186]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, SIBS,CAS Key Lab Nutr Metab & Food Safety, Shanghai 200031, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China; 3.Zhangzhou Hlth Vocat Coll, Dept Pharm, Zhangzhou 363000, Peoples R China; 4.Zhangzhou Hlth Vocat Coll, Dept Med Technol, Zhangzhou 363000, Peoples R China; 5.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100000, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Zhong, Shanshan,Li, Luxiao,Shen, Xia,et al. An update on lipid oxidation and inflammation in cardiovascular diseases[J]. FREE RADICAL BIOLOGY AND MEDICINE,2019,144(SI):266-278. |
| APA | Zhong, Shanshan.,Li, Luxiao.,Shen, Xia.,Tao, Yongzhen.,Yin, Huiyong.,...&,.(2019).An update on lipid oxidation and inflammation in cardiovascular diseases.FREE RADICAL BIOLOGY AND MEDICINE,144(SI),266-278. |
| MLA | Zhong, Shanshan,et al."An update on lipid oxidation and inflammation in cardiovascular diseases".FREE RADICAL BIOLOGY AND MEDICINE 144.SI(2019):266-278. |
入库方式： OAI收割
来源：上海营养与健康研究所
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