Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability
文献类型：期刊论文
| 作者 | Gao, Zhengjun1; Li, Yiyuan1; Wang, Fei1; Huang, Tao1; Fan, Keqi1; Zhong, Jiangyan1; Chao, Tong1; Jia, Junling1; Zhang, Long1; Feng, Xin-Hua1 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:-页码:1805 |
| 关键词 | Electrophysiology Long QT syndrome KCNQ1 Selectivity filter |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-017-01919-0 |
| 文献子类 | Article |
| 英文摘要 | Macrophages, dendritic cells and other innate immune cells are involved in inflammation and host defense against infection. Metabolic shifts in mitochondrial dynamics may be involved in Toll-like receptor agonist-mediated inflammatory responses and immune cell polarization. However, whether the mitochondrial morphology in myeloid immune cells affects anti-tumor immunity is unclear. Here we show that FAM73b, a mitochondrial outer membrane protein, has a pivotal function in Toll-like receptor-regulated mitochondrial morphology switching from fusion to fission. Switching to mitochondrial fission via ablation of Fam73b (also known as Miga2) promotes IL-12 production. In tumor-associated macrophages, this switch results in T-cell activation and enhances anti-tumor immunity. We also show that the mitochondrial morphology affects Parkin expression and its recruitment to mitochondria. Parkin controls the stability of the downstream CHIP-IRF1 axis through proteolysis. Our findings identify mechanisms associated with mitochondrial dynamics that control anti-tumor immune responses and that are potential targets for cancer immunotherapy. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | TUMOR-ASSOCIATED MACROPHAGES ; UBIQUITIN LIGASE CHIP ; NF-KAPPA-B ; PARKINSONS-DISEASE ; ADAPTER PROTEIN ; DENDRITIC CELLS ; IFN-BETA ; FUSION ; FISSION ; DIFFERENTIATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000416293600021 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1190]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Zhejiang Univ, Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China; 2.Zhejiang Univ, Coll Med, Sir Run Run Shaw Hosp, Hangzhou 310016, Zhejiang, Peoples R China; 3.Nanjing Med Univ, Dept Immunol, Nanjing 211166, Jiangsu, Peoples R China; 4.Nanjing Med Univ, State Key Lab Reprod Med, Nanjing 211166, Jiangsu, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China; 6.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China; 7.Zhejiang Univ, Minist Agr, Key Lab Anim Virol, Hangzhou 310058, Zhejiang, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Gao, Zhengjun,Li, Yiyuan,Wang, Fei,et al. Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability[J]. NATURE COMMUNICATIONS,2017,8(-):1805. |
| APA | Gao, Zhengjun.,Li, Yiyuan.,Wang, Fei.,Huang, Tao.,Fan, Keqi.,...&,.(2017).Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability.NATURE COMMUNICATIONS,8(-),1805. |
| MLA | Gao, Zhengjun,et al."Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability".NATURE COMMUNICATIONS 8.-(2017):1805. |
入库方式： OAI收割
来源：上海营养与健康研究所
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