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ABCB5 promotes melanoma metastasis through enhancing NF-kappa B p65 protein stability

文献类型：期刊论文

作者Wang, Shenghao1; Ma, Jie1; Liu, Yanfeng1; Tang, Li2; Lin, Junyu3,4; Wang, Wei3,4; Tao, Shuai3,4; Gu, Chenjian3,4; Xie, Youhua3,4; Shen, Zhongliang5
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2017
卷号492期号:1页码:18-26
关键词Malignant melanoma initiating cells Melanoma Metastasis ABCB5
ISSN号0006-291X
DOI10.1016/j.bbrc.2017.08.052
文献子类Article
英文摘要Melanoma is the most aggressive type of skin cancer. Melanoma has an extremely poor prognosis because of its high potential for vascular invasion, metastasis and recurrence. The mechanism of melanoma metastasis is not well understood. ATP-binding cassette sub-family B member 5 (ABCB5) plays a key role in melanoma growth. However, it is uncertain what function ABCB5 may exert in melanoma metastasis. In this report, we for the first time demonstrate ABCB5 as a crucial factor that promotes melanoma metastasis. ABCB5 positive (ABCB(+)) malignant melanoma initiating cells (MMICs) display a higher metastatic potential compared with ABCB5 negative (ABCB5(-)) melanoma subpopulation. Knockdown of ABCB5 expression reduces melanoma cell migration and invasion in vitro and melanoma pulmonary metastasis in tumor xenograft mice. ABCB5 and NF-kappa B p65 expression levels are positively correlated in both melanoma tissues and cell lines. Consequently, ABCB5 activates the NF-kappa B pathway by inhibiting p65 ubiquitination to enhance p65 protein stability. Our finding highlights ABCB5 as a novel pr-metastasis factor and provides a potential therapeutic target for melanoma. (C) 2017 Elsevier Inc. All rights reserved.
学科主题Biochemistry & Molecular Biology ; Biophysics
WOS关键词MALIGNANT-MELANOMA ; CELLS ; CHEMORESISTANCE ; CD271
语种英语
WOS记录号WOS:000413713300002
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
版本出版稿
源URL[http://202.127.25.144/handle/331004/1192]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Huashan Hosp, Dept Gen Surg, Shanghai, Peoples R China;
2.Shanghai Skin Dis Hosp, Dept Dermatol, Shanghai, Peoples R China;
3.Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Key Lab Med Mol Virol MOE, Shanghai, Peoples R China;
4.Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, MOH, Shanghai, Peoples R China;
5.Fudan Univ, Huashan Hosp, Dept Infect Dis, Shanghai, Peoples R China;
6.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biol Sci, Inst Hlth Sci,Key Lab Stem Cell Biol, Beijing, Peoples R China,
推荐引用方式
GB/T 7714		 Wang, Shenghao,Ma, Jie,Liu, Yanfeng,et al. ABCB5 promotes melanoma metastasis through enhancing NF-kappa B p65 protein stability[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,492(1):18-26.
APA Wang, Shenghao.,Ma, Jie.,Liu, Yanfeng.,Tang, Li.,Lin, Junyu.,...&,.(2017).ABCB5 promotes melanoma metastasis through enhancing NF-kappa B p65 protein stability.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,492(1),18-26.
MLA Wang, Shenghao,et al."ABCB5 promotes melanoma metastasis through enhancing NF-kappa B p65 protein stability".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 492.1(2017):18-26.

入库方式： OAI收割

来源：上海营养与健康研究所

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